FWG-33B
FWG-33B is an activator of TRMT112:METTL5 complex with an IC50 value of 0.47 μM. FWG-33B can be used for the research of breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C24H25ClN2O3
- Peso molecular:424.92
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
FWG-33B (5 μM; 4 hours) engages ~40% of total TRMT112 and >90% of METTL5-complexed TRMT112 in HCT116TRMT112-FLAG:HA-METTL5 cells[1].
FWG-33B (0.01-50 μM; 3 hours pretreatment) stereoselectively engages TRMT112 in HCT116TRMT112-FLAG:HA-METTL5 cells with an IC50 of 1.0 μM[1].
FWG-33B (40 μM; 30 minutes) enhances the methyltransferase activity of WT-TRMT112:METTL5 (but not TRMT112C100A:METTL5) by ~2-fold with 12-nt and 60-nt rRNA substrates[1].
FWG-33B (40 μM; 30 minutes) increases the catalytic efficiency of WT-TRMT112:METTL5 by reducing the Km for rRNA substrate from 10 μM to 4.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Peso molecular 424.92
-
Fòrmula C24H25ClN2O3
-
SMILES
CC(NC(C=C1)=CC=C1O[C@H]2[C@H]3[C@H](CN(C(C=C)=O)C3)[C@@H](C4=CC(Cl)=CC=C4)C2)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FWG-33B Related Classifications
HY-181064 Related Classifications
Powered by Bioz