THUMPD2 - THUMP domain containing 2 Gene

Also Known as C2orf8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80745

About THUMPD2

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:39,736,060-39,779,276 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 6.9), ovary (RPKM 4.8) and 25 other tissues.

Summary

Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]

THUMPD2 Products (11)

mRNA Protein Name
NM_001321468.1 NP_001308397.1 THUMP domain-containing protein 2 isoform 2
NM_001321469.1 NP_001308398.1 THUMP domain-containing protein 2 isoform 3
NM_001321470.1 NP_001308399.1 THUMP domain-containing protein 2 isoform 4
NM_001321474.1 NP_001308403.1 THUMP domain-containing protein 2 isoform 5
NM_001321475.1 NP_001308404.1 THUMP domain-containing protein 2 isoform 6
NM_001321477.1 NP_001308406.1 THUMP domain-containing protein 2 isoform 7
NM_001321478.1 NP_001308407.1 THUMP domain-containing protein 2 isoform 7
NM_001321479.1 NP_001308408.1 THUMP domain-containing protein 2 isoform 7
NM_001321480.1 NP_001308409.1 THUMP domain-containing protein 2 isoform 7
NM_001321481.1 NP_001308410.1 THUMP domain-containing protein 2 isoform 7
NM_025264.5 NP_079540.2 THUMP domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THUMPD2 Protein Structure

THUMP

THUMP: THUMP domain (180 - 255)

UPF0020

UPF0020: Putative RNA methylase family UPF0020 (274 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

THUMP domain-containing protein 2

  • SAM-dependent methyltransferase

THUMPD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THUMPD2 Q9BTF0 TRMT112 Homo sapiens Q9UI30
Confocal
34948388
Intra
THUMPD2 Q9BTF0 TRMT112 Homo sapiens Q9UI30
Anti Tag CoIP
34948388
Intra
THUMPD2 Q9BTF0 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
THUMPD2 Q9BTF0 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
THUMPD2 Q9BTF0 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gingival Fibromatosis

  • Hereditary Gingival Fibromatosis

  • Hereditary Gingival Hyperplasia

  • Autosomal Dominant Gingival Fibromatosis

  • Autosomal Dominant Gingival Hyperplasia

  • Fibromatosis, Gingival, Hereditary

  • Fibromatosis, Gingival
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14509 THUMPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus THUMPD2 VGNC VGNC:66179
Bos taurus THUMPD2 VGNC VGNC:35854
Mus musculus THUMPD2 MGD MGI:1919417
Canis familiaris THUMPD2 VGNC VGNC:47361
Macaca mulatta THUMPD2 VGNC VGNC:78384
Rattus norvegicus THUMPD2 RGD RGD:1306878
Others THUMPD2 NCBI