CANX - calnexin Gene

Also Known as CNX; P90; IP90

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 821

About CANX

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,678,656-179,731,641 (from NCBI)

This gene has 47 transcripts (splice variants), 1 gene allele, 212 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 267.4), placenta (RPKM 108.5) and 25 other tissues.

Summary

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]

CANX Products (11)

mRNA	Protein	Name
NM_001024649.2	NP_001019820.1	calnexin isoform d precursor
NM_001363993.1	NP_001350922.1	calnexin isoform a
NM_001363994.1	NP_001350923.1	calnexin isoform b
NM_001363995.1	NP_001350924.1	calnexin isoform c precursor
NM_001363996.1	NP_001350925.1	calnexin isoform d precursor
NM_001363997.1	NP_001350926.1	calnexin isoform d precursor
NM_001363998.1	NP_001350927.1	calnexin isoform e precursor
NM_001363999.1	NP_001350928.1	calnexin isoform f precursor
NM_001364000.1	NP_001350929.1	calnexin isoform g
NM_001364001.1	NP_001350930.1	calnexin isoform g
NM_001746.4	NP_001737.1	calnexin isoform d precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16361248	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14966132	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	19723497	GOA
NOT located in extracellular exosome	IDA IDA: Inferred from direct assay	21235781	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	23455425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CANX Protein Structure

Calreticulin

0
100
200
300
400
500
592 a.a.

Protein Preferred Names	Protein Names
calnexin	epididymis secretory sperm binding protein

CANX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CANX	P27824	CYB5R3	Homo sapiens	P00387	Anti Tag CoIP	35271311
Intra	CANX	P27824	CYB5R3	Homo sapiens	P00387	Crosslink	30021884
Intra	CANX	P27824	CNTNAP2	Homo sapiens	Q9UHC6-1	Anti Tag CoIP	22872700
Intra	CANX	P27824	CFTR	Homo sapiens	P13569	CoIP	12208510
Intra	CANX	P27824	RPL12	Homo sapiens	P30050	Anti Tag CoIP	22314232
Intra	CANX	P27824	RPL12	Homo sapiens	P30050	Anti Bait CoIP	22314232
Intra	CANX	P27824	SEC61A1	Homo sapiens	P61619	Anti Tag CoIP	22314232
Intra	CANX	P27824	SEC61A1	Homo sapiens	P61619	Pull Down	29568061
Intra	CANX	P27824	SEC61A1	Homo sapiens	P61619	Anti Tag CoIP	35271311
Intra	CANX	P27824	SSR1	Homo sapiens	P43307	Anti Bait CoIP	22314232
Intra	CANX	P27824	SSR1	Homo sapiens	P43307	Anti Bait CoIP	17380188
Intra	CANX	P27824	SSR1	Homo sapiens	P43307	Anti Tag CoIP	22314232
Intra	CANX	P27824	SSR1	Homo sapiens	P43307	Pull Down	29568061
Intra	CANX	P27824	SSR1	Homo sapiens	P43307	Anti Tag CoIP	35271311
Intra	CANX	P27824	NDRG1	Homo sapiens	Q92597	Anti Bait CoIP	17220478
Cross	CANX	P27824	env	Human immunodeficiency virus	P04578	Anti Bait CoIP	25170080

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CANX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7711	Calnexin Protein, Human (HEK293, His)	P27824 (H21-P481)	≥ 95%, as determined by reducing SDS-PAGE.

CANX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80041	Calnexin Antibody (YA573)	WB, ICC/IF, IHC-P, FC	Human, Rat
HY-P80578	Calnexin Antibody	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85072	Calnexin Antibody (YA4764)	WB, ICC/IF, ELISA	Human
HY-P85072A	Calnexin Antibody (YA4764)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P86146	Calnexin Antibody (YA5838)	WB, IHC-P, ICC/IF, IP, ELISA	Human

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Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01879	CANX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18340	Canx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24819	Canx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CANX	VGNC	VGNC:26736
Macaca mulatta	CANX	VGNC	VGNC:70527
Felis catus	CANX	VGNC	VGNC:60345
Rattus norvegicus	CANX	RGD	RGD:2266
Canis familiaris	CANX	VGNC	VGNC:38695
Mus musculus	CANX	MGD	MGI:88261
Others	CANX	NCBI