Calnexin Antibody (YA4764)
(Synonyms: CANX; Calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90)
Based on 1 Customer Validation
Calnexin Antibody (YA4764) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Calnexin.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
Calnexin Antibody (YA4764) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Calnexin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 68 kDa;
Synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.
affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Calnexin is a Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse
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Subcellular Localization
Endoplasmic reticulum membrane; Single-pass type I membrane protein; Mitochondrion membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein
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Isoforms & Post-Translational Modification
P27824 has 3 isomers: P27824-1: 67568 Da (predicted); P27824-2: 71503 Da (predicted); P27824-3: 55598 Da (predicted).
Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity);Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins;Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4 -
Subunit
Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity).
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SwissProt ID
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Synonyms
CANX; Calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
Documentation
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