Gly-Gly-Gly-PEG4-DBCO

Name: Gly-Gly-Gly-PEG4-DBCO
Brand: MedChemExpress
SKU: HY-140309
Rating: 4.5 (0 reviews)

Cat. No.: HY-140309 Purity: 95.19%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Gly-Gly-Gly-PEG4-DBCO is a 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Gly-Gly-Gly-PEG4-DBCO 화학구조

CAS No. : 2353409-80-8

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Gly-Gly-Gly-PEG4-DBCO is a 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

694.77

화학식

C₃₅H₄₆N₆O₉

CAS No.

2353409-80-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCNC(CNC(CNC(CN)=O)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (143.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4393 mL	7.1966 mL	14.3933 mL
5 mM	0.2879 mL	1.4393 mL	2.8787 mL
10 mM	0.1439 mL	0.7197 mL	1.4393 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.19%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (242 KB) HNMR (324 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4393 mL	7.1966 mL	14.3933 mL	35.9831 mL
	5 mM	0.2879 mL	1.4393 mL	2.8787 mL	7.1966 mL
	10 mM	0.1439 mL	0.7197 mL	1.4393 mL	3.5983 mL
	15 mM	0.0960 mL	0.4798 mL	0.9596 mL	2.3989 mL
	20 mM	0.0720 mL	0.3598 mL	0.7197 mL	1.7992 mL
	25 mM	0.0576 mL	0.2879 mL	0.5757 mL	1.4393 mL
	30 mM	0.0480 mL	0.2399 mL	0.4798 mL	1.1994 mL
	40 mM	0.0360 mL	0.1799 mL	0.3598 mL	0.8996 mL
	50 mM	0.0288 mL	0.1439 mL	0.2879 mL	0.7197 mL
	60 mM	0.0240 mL	0.1199 mL	0.2399 mL	0.5997 mL
	80 mM	0.0180 mL	0.0900 mL	0.1799 mL	0.4498 mL
	100 mM	0.0144 mL	0.0720 mL	0.1439 mL	0.3598 mL