GPR35 agonist 3

Cat. No.: HY-131728 Purity: 98.32%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GPR35 agonist 3 is a synthetic GPR35 agonist with an EC₅₀value of 1.4 μM. GPR35 agonist 3 can be used for the research of various diseases, such as gastric cancer, type 2 diabetes, cardiovascular diseases, immune system and peripheral nervous system.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

GPR35 agonist 3 화학구조

CAS No. : 123021-85-2

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

EC50: 1.4 μM (GPR35)^[1].
Ki: 0.0508 μM (GPR35)^[1].
IC50: 0.349 μM (GPR35)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.349 μM Compound: 3	Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay	[PMID: 23888932]
HEK-293T	EC₅₀	1.4 μM Compound: 3	Agonist activity at human GPR35 expressed in HEK293T cells at 5 uM by EYPF-based beta-arrestin-2 luciferase reporter gene assay Agonist activity at human GPR35 expressed in HEK293T cells at 5 uM by EYPF-based beta-arrestin-2 luciferase reporter gene assay	[PMID: 23888932]

In Vitro

GPR35 agonist 3 (compound 3) shows GPR35 agonist potency with an EC₅₀ value of 1.4 μM^[1].
GPR35 agonist 3 has affinity and potency for GPR35 with values of 0.0508 μM (K_i) and 0.349 μM (IC₅₀)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

279.27

화학식

C₁₂H₉NO₅S

CAS No.

123021-85-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(/C=C(SC(N2)=O)\C2=O)C=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 125 mg/mL (447.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5808 mL	17.9038 mL	35.8076 mL
5 mM	0.7162 mL	3.5808 mL	7.1615 mL
10 mM	0.3581 mL	1.7904 mL	3.5808 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.32%

Select Batch:

Data Sheet (270 KB) SDS (392 KB)

COA (247 KB) HNMR (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Dominik Thimm, et al. 6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35. J Med Chem [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5808 mL	17.9038 mL	35.8076 mL	89.5191 mL
	5 mM	0.7162 mL	3.5808 mL	7.1615 mL	17.9038 mL
	10 mM	0.3581 mL	1.7904 mL	3.5808 mL	8.9519 mL
	15 mM	0.2387 mL	1.1936 mL	2.3872 mL	5.9679 mL
	20 mM	0.1790 mL	0.8952 mL	1.7904 mL	4.4760 mL
	25 mM	0.1432 mL	0.7162 mL	1.4323 mL	3.5808 mL
	30 mM	0.1194 mL	0.5968 mL	1.1936 mL	2.9840 mL
	40 mM	0.0895 mL	0.4476 mL	0.8952 mL	2.2380 mL
	50 mM	0.0716 mL	0.3581 mL	0.7162 mL	1.7904 mL
	60 mM	0.0597 mL	0.2984 mL	0.5968 mL	1.4920 mL
	80 mM	0.0448 mL	0.2238 mL	0.4476 mL	1.1190 mL
	100 mM	0.0358 mL	0.1790 mL	0.3581 mL	0.8952 mL

GPR35 agonist 3 Related Classifications

Neurological Disease Metabolic Disease Inflammation/Immunology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR35 agonist 3123021-85-2GPR35G Protein-Coupled Receptor 35agonistgastric cancertype 2 diabetescardiovascular diseasesimmune systemperipheral nervous systemInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *

회사명 *

Country or Region *

비고

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

GPR35 agonist 3

GPR35 agonist 3 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

GPR35 agonist 3 Related Antibodies

몰농도 계산기

농도 희석 계산기