HAIYPRH hydrochloride

Name: HAIYPRH hydrochloride
Brand: MedChemExpress
SKU: HY-P2314
Rating: 4.5 (0 reviews)

製品番号: HY-P2314 純度: 99.97%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

カスタムペプチド

HAIYPRH hydrochloride 構造式

容量	価格（税別）	在庫状況	数量
5 mg	$70	在庫あり	Estimated Time of Arrival: December 31
10 mg	$120	在庫あり	Estimated Time of Arrival: December 31
25 mg	$200	在庫あり	Estimated Time of Arrival: December 31
50 mg	$300	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier^[1].

体外実験

HAIYPRH hydrochloride (T7) is conjugated to liposomes for ischemic stroke targeting treatment of a novel neuroprotectant (HY-100456: ZL006)^[2].
HAIYPRH hydrochloride is a heptapeptide that can be used to target gliomas^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

HAIYPRH hydrochloride, a transferrin receptor-specific peptide, is chosen as the ligand to target the co-delivery system to the tumor cells expressing transferrin receptors. HAIYPRH-modified co-delivery system shows higher efficiency in cellular uptake and gene expression than unmodified co-delivery system in U87 MG cells, and accumulated in tumor more efficiently in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

929.46

分子式

C₄₁H₆₁ClN₁₄O₉

Appearance

Solid

Color

White to off-white

Sequence Shortening

HAIYPRH

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)

溶剤 & 溶解度

体外:

H₂O : ≥ 100 mg/mL (107.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0759 mL	5.3795 mL	10.7589 mL
5 mM	0.2152 mL	1.0759 mL	2.1518 mL
10 mM	0.1076 mL	0.5379 mL	1.0759 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.97%

Select Batch:

データシート (279 KB) SDS (252 KB)

COA (258 KB) RP-HPLC (267 KB) MS (71 KB) Elemental Analysis Report (118 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Liu S, et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012;33(19):4907‐4916. [Content Brief]

[2]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015;5:12651. Published 2015 Jul 29. [Content Brief]

[3]. Ziyang Zhu, et al. Goat milk-derived exosomes Endowed with Radioactive and Targeting Properties: potential to provide PET/CT monitoring for exosomes-based drug delivery system in gliomas therapy. J Nucl Med May 1, 2020 vol. 61.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0759 mL	5.3795 mL	10.7589 mL	26.8973 mL
	5 mM	0.2152 mL	1.0759 mL	2.1518 mL	5.3795 mL
	10 mM	0.1076 mL	0.5379 mL	1.0759 mL	2.6897 mL
	15 mM	0.0717 mL	0.3586 mL	0.7173 mL	1.7932 mL
	20 mM	0.0538 mL	0.2690 mL	0.5379 mL	1.3449 mL
	25 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0759 mL
	30 mM	0.0359 mL	0.1793 mL	0.3586 mL	0.8966 mL
	40 mM	0.0269 mL	0.1345 mL	0.2690 mL	0.6724 mL
	50 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.5379 mL
	60 mM	0.0179 mL	0.0897 mL	0.1793 mL	0.4483 mL
	80 mM	0.0134 mL	0.0672 mL	0.1345 mL	0.3362 mL
	100 mM	0.0108 mL	0.0538 mL	0.1076 mL	0.2690 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.