HBTU (Synonyms: N-HBTU)

Cat. No.: HY-Y0912 Purity: 99.35%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma.

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HBTU 화학구조

CAS No. : 94790-37-1

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
500 g	해외재고보유	Estimated Time of Arrival: December 31
1 kg	해외재고보유	Estimated Time of Arrival: December 31

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

N-HBTU supports standard solid-phase synthesis of the biotinylated Mon1 peptide, and optimized N-Dcpm protected dipeptide building blocks are predicted to be compatible with standard N-HBTU coupling protocols for Asp-Gly-containing peptides^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

379.24

화학식

C₁₁H₁₆F₆N₅OP

CAS No.

94790-37-1

Appearance

Solid

Color

White to off-white

SMILES

F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=CC=CC=C2N=N1

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 200 mg/mL (527.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6369 mL	13.1843 mL	26.3685 mL
5 mM	0.5274 mL	2.6369 mL	5.2737 mL
10 mM	0.2637 mL	1.3184 mL	2.6369 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.80%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) RP-HPLC (109 KB)

Handling Instructions (2659 KB)

References

[1]. Dubey L V, et al. Side reactions of onium coupling reagents BOP and HBTU in the synthesis of silica polymer supports[J]. Ukrainica bioorganica acta, 2005, 1: 13-19.

[2]. Röder R, et al. On the use of N-dicyclopropylmethyl aspartyl-glycine synthone for backbone amide protection. J Pept Sci. 2010;16(1):65-70. [Content Brief]

[3]. McKnelly KJ, et al. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. J Org Chem. 2020;85(3):1764-1768. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6369 mL	13.1843 mL	26.3685 mL	65.9213 mL
	5 mM	0.5274 mL	2.6369 mL	5.2737 mL	13.1843 mL
	10 mM	0.2637 mL	1.3184 mL	2.6369 mL	6.5921 mL
	15 mM	0.1758 mL	0.8790 mL	1.7579 mL	4.3948 mL
	20 mM	0.1318 mL	0.6592 mL	1.3184 mL	3.2961 mL
	25 mM	0.1055 mL	0.5274 mL	1.0547 mL	2.6369 mL
	30 mM	0.0879 mL	0.4395 mL	0.8790 mL	2.1974 mL
	40 mM	0.0659 mL	0.3296 mL	0.6592 mL	1.6480 mL
	50 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3184 mL
	60 mM	0.0439 mL	0.2197 mL	0.4395 mL	1.0987 mL
	80 mM	0.0330 mL	0.1648 mL	0.3296 mL	0.8240 mL
	100 mM	0.0264 mL	0.1318 mL	0.2637 mL	0.6592 mL

HBTU Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBTU94790-37-1N-HBTUBiochemical Assay Reagentsdermatitisbiotinylated Mon1 peptidesolid-phase peptide synthesisbronchial asthmaFmoc/tBu strategyguanidinium (uronium) peptide coupling reagentimmune sensitizerrhinitissterically hindered amino acid/dipeptide derivativesanaphylaxisInhibitorinhibitorinhibit

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HBTU (Synonyms: N-HBTU)

HBTU Related Antibodies

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Biological Activity

순도&문서

References

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HBTU Related Antibodies

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