94790-37-1
Chemical Structure
HBTU
Synonym(s): N-HBTU
- CAS No.: 94790-37-1
- Formula:C11H16F6N5OP
- Molecular Weight:379.24
IUPAC Name: 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(V)
InChIKey: UQYZFNUUOSSNKT-UHFFFAOYSA-N
SMILES: F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=CC=CC=C2N=N1
Biological Activity: HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HBTU | 99.35% | HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma. | ||||||||||||||||||||
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- [1]. Dubey L V, et al. Side reactions of onium coupling reagents BOP and HBTU in the synthesis of silica polymer supports[J]. Ukrainica bioorganica acta, 2005, 1: 13-19.
- [2]. Röder R, et al. On the use of N-dicyclopropylmethyl aspartyl-glycine synthone for backbone amide protection. J Pept Sci. 2010;16(1):65-70. [Content Brief]
- [3]. McKnelly KJ, et al. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. J Org Chem. 2020;85(3):1764-1768. [Content Brief]
Keywords
