HDAC-IN-70 

HDAC-IN-70 (compound 4c) is HDAC6 inhibitor with the IC₅₀ values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively. HDAC-IN-70 induces cell cycle arrest, apoptosis and necrotic. HDAC-IN-70 can be used for study of leukemia^[1].

HDAC-IN-70 (compound 4c) (0-120 μM) shows cytotoxic activity against CCRF-CEM and MOLT-4 cells with the IC₅₀ values of 1.82 , 6.73 μM^[1].
HDAC-IN-70 (1.82 μM, 24 h) arrests cell cycle at G2-M phase in CCRF-CEM cells^[1].
HDAC-IN-70 (1.82 μM, 24 h) increases the percentage of total apoptosis and necrotic in CCRF-CEM cells^[1].
HDAC-IN-70 (1.82 μM, 24 h) increases the level of acetylated histones H3, H4 in CCRF-CEM leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.33

C₁₈H₁₄N₄O₃

O=C(CC1C(NC(N1)=O)=O)N2C3=CC=CC=C3N=C2C4=CC=CC=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abdulwahab HG, et al. Discovery of novel benzimidazole derivatives as potent HDACs inhibitors against leukemia with (Thio)Hydantoin as zinc-binding moiety: Design, synthesis, enzyme inhibition, and cellular mechanistic study. Bioorg Chem. Published online March 13, 2024.  [Content Brief]