2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. HIT-2

HIT-2 is an estrogen receptor alpha (ERα) inhibitor that can bind to the ERα ligand binding domain. HIT-2 forms stable interactions including hydrogen bonds, π-π stacking, and hydrophobic contacts to disrupt ERα-driven signaling. HIT-2 exhibits antineoplastic activity against breast cancer. HIT-2 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

HIT-2

HIT-2 Chemical Structure

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HIT-2 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

HIT-2 is an estrogen receptor alpha (ERα) inhibitor that can bind to the ERα ligand binding domain. HIT-2 forms stable interactions including hydrogen bonds, π-π stacking, and hydrophobic contacts to disrupt ERα-driven signaling. HIT-2 exhibits antineoplastic activity against breast cancer. HIT-2 can be used for the research of breast cancer[1].

IC50 & Target[1]

ERα

 

In Vitro

HIT-2 is predicted to fallunder Class IV oral toxicity, with an LD50 value of 830 mg/kg, indicating it is harmful if ingested but remains within an acceptable toxicity threshold for early[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIT-2 Related Antibodies
Molecular Weight

376.47

Formula

C22H20N2O2S
SMILES

CC(C=C1)=CC=C1C2=NC3=CC=CC=C3S[C@@H](C4=CC(N(O)O)=CC=C4)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIT-2 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIT-2HIT2HIT 2Estrogen Receptor/ERRhydrophobic contactsπ-π stackingERαestrogen receptor alphabreast cancerhydrogen bondsERα ligand binding domainERα-driven signalingInhibitorinhibitorinhibit

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