2. Anti-infection Metabolic Enzyme/Protease
  3. HCV HCV Protease
  4. IDX184

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM).

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IDX184

IDX184 構造式

CAS 番号 : 1036915-08-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1130 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1130 在庫あり
Solid
1 mg $328 在庫あり
5 mg $820 在庫あり
10 mg $1320 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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IDX184 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM)[1][2].

IC50 & Target

IC50: 0.31 μM (HCV polymerase)[2]
Ki: 52.3 nM (HCV polymerase)[2]
Cellular Effect
Cell Line Type Value Description References
CCRF-CEM CC50
>100 μM
Compound: 2; IDX-184
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
[PMID: 26819659]
Huh-7 CC50
>100 μM
Compound: 2; IDX-184
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
[PMID: 26819659]
PBMC CC50
>100 μM
Compound: 2; IDX-184
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
[PMID: 26819659]
Vero CC50
>100 μM
Compound: 2; IDX-184
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
[PMID: 26819659]
体外実験

IDX184 is a liver-targeted prodrug of the nucleotide 2′-MeG-MP. IDX184 is a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus[1].
IDX184 is a second generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM). IDX184 is not toxic (CC50>100μM) in any tested cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDX184 関連抗体
臨床実験
分子量

626.62

分子式

C25H35N6O9PS
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@](O[C@@H]1CO[P](NCC2=CC=CC=C2)(OCCSC(C(C)(C)CO)=O)=O)([H])N3C(NC(N)=NC4=O)=C4N=C3)([C@@H]1O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 250 mg/mL (398.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5959 mL 7.9793 mL 15.9586 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL
10 mM 0.1596 mL 0.7979 mL 1.5959 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5959 mL 7.9793 mL 15.9586 mL 39.8966 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL 7.9793 mL
10 mM 0.1596 mL 0.7979 mL 1.5959 mL 3.9897 mL
15 mM 0.1064 mL 0.5320 mL 1.0639 mL 2.6598 mL
20 mM 0.0798 mL 0.3990 mL 0.7979 mL 1.9948 mL
25 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5959 mL
30 mM 0.0532 mL 0.2660 mL 0.5320 mL 1.3299 mL
40 mM 0.0399 mL 0.1995 mL 0.3990 mL 0.9974 mL
50 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7979 mL
60 mM 0.0266 mL 0.1330 mL 0.2660 mL 0.6649 mL
80 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4987 mL
100 mM 0.0160 mL 0.0798 mL 0.1596 mL 0.3990 mL
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IDX184 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDX1841036915-08-8IDX 184IDX-184HCVHCV ProteaseHepatitis C virusreplicationJFH-1infectiousInhibitorinhibitorinhibit

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製品名:
IDX184
製品番号:
HY-19558
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