2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Ordastobart

Ordastobart  (Synonyms: INBRX-106; ES-102)

Cat. No.: HY-P991336 Pureza: 98%
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Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer.

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No. CAS : 2708115-83-5

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Ordastobart Related Antibodies

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Descripciòn

Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer[1].

Isotype

[G1 VH-VH-VH-h-CH2-CH3]-dimer
Species Reactivity

Human
IC50 & Target

TNFRSF4/OX40/CD134
In Vitro

Ordastobart (5-25 nM, 1 h at 37°C) induces high clustering of the OX40 receptor in CHO cells expressing a human OX40 extracellular domain coupled to GFP[1].
Ordastobart (0.001-1000 nM, 96 h) stimulates CD4+ and CD8+ cells enriched from PBMC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ordastobart Related Antibodies

Immunofluorescence[1]

Cell Line: CHO cells expressing a human OX40 extracellular domain coupled to GFP
Concentration: 5, 25 nM
Incubation Time: 1 h at 37°C
Result: Enhanced high-level co-occurrence of GFP (green) and AF647 (magenta) on the cell membrane.

Cell Proliferation Assay[1]

Cell Line: CD4+ and CD8+ T cells enriched from healthy donor peripheral blood mononuclear cells (PBMC)
Concentration: 0.001, 0.01, 0.1, 1, 10, 100, 1000 nM
Incubation Time: 96 h at 37°C
Result: Increaseed human leukocyte antigen (HLA)-DR expression, with maximum activity reaching a peak between 0.1-10 nM and declining at concentrations above 10 nM.
In Vivo

Ordastobart (10  µg/single dose, i.v.) exhibits antitumor activity by inducing robust CD8+ T cell expansion and effector differentiation in MCA-205 or CT26 tumor-bearing mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCA-205 (C57BL/6) or CT26 (BALB/c) tumor-bearing (106) mice (6-8 weeks old, female) model[1]
Dosage: 10  µg/single dose
Administration: i.v.
Result: Demonstrated good tolerability, reduced tumor size, and significantly improved survival.
Engaged and activated CD8+ T cells to control tumor growth.
Expanded CD8+ T cells within tumors and increases T cell frequency and proliferation within LNs; reduces CD8+ T cell frequency in tdLNs but increases proliferation Ki-67.
Increased CD4+ Teff proliferation as compared with controls, enhanced interferon (IFN)-γ and TNF-α production.
Increased the frequency of CD8+ T cells and decreased the frequency of Tregs compared with controls.
Ensayo clínico
Gene ID

7293  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

128.96 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ordastobart]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • VH-VH-VH-h-CH2-CH3
Biological Activity
  • Loaded Ordastobart on ProA biosensor, can bind OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78189) with an affinity constant of 1.30E-10 M as determined in BLI assay.
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Referencias
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Ordastobart Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ordastobart2708115-83-5INBRX-106 ES-102INBRX106INBRX 106ES102ES 102ES-102Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorAgonistAntibodyMCA-205 cellsCT26 cellsCD4+ cellsCD8+ cellsfibrosarcomacolorectalInhibitorinhibitorinhibit

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Nombre del producto:
Ordastobart
Cat. No.:
HY-P991336
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