JMV 449

Art. -Nr.: HY-P1256: Data Sheet Handling Instructions
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JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

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JMV 449 Chemische Struktur

CAS. Nr. : 139026-66-7

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of JMV 449:

JMV 449 acetate

Other Forms of JMV 449:

JMV 449 acetate In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Neurotensin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

NTR1 NTR2

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

In Vivo

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss albino mice^[2]
Dosage:	120 pmol/mouse
Administration:	i.c.v.
Result:	Showed dose-response relation-ships for the analgesic effect.

Molekulargewicht

746.98

Formel

C₃₈H₆₆N₈O₇

CAS. Nr.

139026-66-7

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [Content Brief]

[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329. [Content Brief]

JMV 449 Related Classifications

Neurological Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMV 449139026-66-7JMV449JMV-449Neurotensin Receptorpseudopeptideanalogueneurotensin8-13hypothermicneuroprotectiveInhibitorinhibitorinhibit

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