JMV 449

Cat. No.: HY-P1256: Fiche technique Instruction de manipulation
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JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

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JMV 449 Chemical Structure

CAS No. : 139026-66-7

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of JMV 449:

JMV 449 acetate

Other Forms of JMV 449:

JMV 449 acetate In-stock

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Neurotensin Receptor:

Voir toutes les isoformes

NTR1 NTR2

Activité biologique
Pureté et documentation
Références
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Description

In Vivo

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss albino mice^[2]
Dosage:	120 pmol/mouse
Administration:	i.c.v.
Result:	Showed dose-response relation-ships for the analgesic effect.

Masse moléculaire

746.98

Formule

C₃₈H₆₆N₈O₇

CAS No.

139026-66-7

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [Content Brief]

[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329. [Content Brief]

JMV 449 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMV 449139026-66-7JMV449JMV-449Neurotensin Receptorpseudopeptideanalogueneurotensin8-13hypothermicneuroprotectiveInhibitorinhibitorinhibit

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