2. Cell Cycle/DNA Damage
  3. p97
  4. KUS121

KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.

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KUS121

KUS121 Estructura química

No. CAS : 1357164-52-3

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
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10 mg En stock
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KUS121 Related Antibodies

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Descripciòn

KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress[1][2].

In Vitro

KUS121 protects neurons from cell death under oxygen glucose deprivation (OGD) by preventing ATP depletion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KUS121 Related Antibodies
In Vivo

KUS121 (IVT injection, 25 μg/eye) appears to show a better suppression of inner retinal thinning 7 and 14 days after the ischemic insult. KUS121 (IVT injection) also shows a better preservation of GFP-positive RGCs and equally preserved b-wave amplitude 14 days after the insult. KUS121 (IVT injection) also exerts neuroprotective effects on retinal morphology and function after ischemic damage[1].
KUS121 suppresses thinning of the outer nuclear layer and maintained visual function. KUS121 (retinas) suppresses endoplasmic reticulum stress, activates mammalian target of rapamycin and suppresses disease-associated apoptosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

458.44

Fòrmula

C22H16FN4NaO3S
No. CAS
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=S(C1=C2C=CC=CC2=C(N)C(/N=N/C3=CC=C(C4=CC=C(C=C4C)F)N=C3)=C1)(O[Na])=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 58.33 mg/mL (127.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1813 mL 10.9066 mL 21.8131 mL
5 mM 0.4363 mL 2.1813 mL 4.3626 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1813 mL 10.9066 mL 21.8131 mL 54.5328 mL
5 mM 0.4363 mL 2.1813 mL 4.3626 mL 10.9066 mL
10 mM 0.2181 mL 1.0907 mL 2.1813 mL 5.4533 mL
15 mM 0.1454 mL 0.7271 mL 1.4542 mL 3.6355 mL
20 mM 0.1091 mL 0.5453 mL 1.0907 mL 2.7266 mL
25 mM 0.0873 mL 0.4363 mL 0.8725 mL 2.1813 mL
30 mM 0.0727 mL 0.3636 mL 0.7271 mL 1.8178 mL
40 mM 0.0545 mL 0.2727 mL 0.5453 mL 1.3633 mL
50 mM 0.0436 mL 0.2181 mL 0.4363 mL 1.0907 mL
60 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9089 mL
80 mM 0.0273 mL 0.1363 mL 0.2727 mL 0.6817 mL
100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.5453 mL
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KUS121 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KUS1211357164-52-3KUS 121KUS-121p97VCPCdc48neuroprotectiveoxygen glucose deprivationOGDER stressischemic damageInhibitorinhibitorinhibit

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Nombre del producto:
KUS121
Cat. No.:
HY-138233
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