1. Cell Cycle/DNA Damage
    Apoptosis
  2. DNA/RNA Synthesis
    DNA Alkylator/Crosslinker
    Apoptosis
  3. Mafosfamide sodium salt

Mafosfamide sodium salt (Synonyms: Z 7557 sodium salt; cis-Mafosfamide sodium salt)

Cat. No.: HY-100628A Purity: >95.0%
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Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity.

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Mafosfamide sodium salt Chemical Structure

Mafosfamide sodium salt Chemical Structure

CAS No. : 84211-05-2

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Description

Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity[1][2].

In Vitro

Mafosfamide sodium salt (Z 7557 sodium salt; 2-10 μg/ml; 72 hours) triggers apoptosis in a dose and time dependent manner[1].
Mafosfamide sodium salt (2-10 μg/ml; 24 hours) causes the cells accumulated in S-phase[1].
Mafosfamide sodium salt (10 μg/ml; 24-72 hours) causes p53 stabilization[1].
Mafosfamide sodium salt (10 μg/ml) induces transcriptional inhibition that contributes to the apoptotic response combined with α-amanitin[1].

Apoptosis Analysis[1]

Cell Line: TK6 and WTK1 cells
Concentration: 2, 10 μg/ml
Incubation Time: 72 hours
Result: Triggered apoptosis in a dose and time dependent manner.
Preferentially induced apoptosis (> 70% of dead cells) in both p53wt and p53mt cells, with necrosis only induced at low levels (< 30% of dead cells).

Cell Cycle Analysis[1]

Cell Line: TK6 and WTK1 cells
Concentration: 2, 10 μg/ml
Incubation Time: 24 hours
Result: The cells accumulated in S-phase.

Western Blot Analysis[1]

Cell Line: TK6 and WTK1 cells
Concentration: 10 μg/ml
Incubation Time: 24, 48, 72 hours
Result: Caused p53 stabilization by phosphorylation of Ser15, 20 and 37, and activation of ATM/ATR and Chk1/Chk2.
Molecular Weight

423.25

Formula

C₉H₁₈Cl₂N₂NaO₅PS₂

CAS No.

84211-05-2

SMILES

ClCCN([[email protected]@]1(OCC[[email protected]@H](SCCS(=O)(O[Na])=O)N1)=O)CCCl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

References

Purity: >95.0%

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Keywords:

MafosfamideZ 7557cis-MafosfamideZ7557Z-7557DNA/RNA SynthesisDNA Alkylator/CrosslinkerApoptosisnuclearDNAcross-linkscyclophosphamidelymphoblastoidp53Ser152037ATM/ATRChk1/Chk2PI3-kinaseInhibitorinhibitorinhibit

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Mafosfamide sodium salt
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