1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. GR231118 TFA

GR231118 TFA (Synonyms: 1229U91 TFA; GW1229 TFA)

Cat. No.: HY-P1321A
Handling Instructions

GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8).

For research use only. We do not sell to patients.

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GR231118 TFA Chemical Structure

GR231118 TFA Chemical Structure

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Description

GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8)[1].

Molecular Weight

2466.76

Formula

C₁₁₂H₁₇₁F₃N₃₄O₂₆

Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1':IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4';Dpr4-Glu2')

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GR2311181229U91GW1229GR 231118GR-231118GW 1229GW-1229Neuropeptide Y ReceptorNPY receptorNeuropeptideantagonistanalogueradioligandC-terminusInhibitorinhibitorinhibit

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GR231118 TFA
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