Search Result

Results for "

Neuropeptide

" in MCE Product Catalog:

By Targets:	Neuropeptide Y Receptor (72) 5-HT Receptor (2) Adenylate Cyclase (1) Amyloid-β (3) Angiotensin Receptor (1) Apoptosis (1) Bombesin Receptor (1) Calcium Channel (3) CGRP Receptor (5) CRFR (7) Dopamine Receptor (1) Endogenous Metabolite (6) Fluorescent Dye (1) G protein-coupled Bile Acid Receptor 1 (2) G Protein-coupled Receptor Kinase (GRK) (1) GCGR (2) iGluR (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) MCHR1 (GPR24) (3) Melanocortin Receptor (3) Neurokinin Receptor (21) Opioid Receptor (7) Orexin Receptor (OX Receptor) (7) Oxytocin Receptor (1) Potassium Channel (2) Prolyl Endopeptidase (PREP) (1) Sodium Channel (1) Somatostatin Receptor (6) Thyroid Hormone Receptor (2) TRP Channel (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (23) Endocrinology (45) Inflammation/Immunology (10) Metabolic Disease (27) Neurological Disease (171)

By Targets:

Neuropeptide Y Receptor (72)

5-HT Receptor (2)

Adenylate Cyclase (1)

Amyloid-β (3)

Angiotensin Receptor (1)

Apoptosis (1)

Bombesin Receptor (1)

Calcium Channel (3)

CGRP Receptor (5)

CRFR (7)

Dopamine Receptor (1)

Endogenous Metabolite (6)

Fluorescent Dye (1)

G protein-coupled Bile Acid Receptor 1 (2)

G Protein-coupled Receptor Kinase (GRK) (1)

GCGR (2)

iGluR (2)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

MCHR1 (GPR24) (3)

Melanocortin Receptor (3)

Neurokinin Receptor (21)

Opioid Receptor (7)

Orexin Receptor (OX Receptor) (7)

Oxytocin Receptor (1)

Potassium Channel (2)

Prolyl Endopeptidase (PREP) (1)

Sodium Channel (1)

Somatostatin Receptor (6)

Thyroid Hormone Receptor (2)

TRP Channel (1)

Vasopressin Receptor (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (23)

Endocrinology (45)

Inflammation/Immunology (10)

Metabolic Disease (27)

Neurological Disease (171)

158

Inhibitors & Agonists

Fluorescent Dye

168

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Targets Recommended: Neuropeptide Y Receptor

Cat. No.	Product Name	Target	Research Areas

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC₅₀ values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀ of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.

HY-148179

Neuropeptide Y5 receptor ligand-1	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y5 receptor ligand-1 (compound 54), a carbazole derivative, is a potent neuropeptide Y5 (NPY-5) receptor antagonist.

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.

HY-P3678

Neuropeptide Y (18-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC₅₀ value of 158 nM and an K_i value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.

HY-P1437A

Neuropeptide S(Mouse) TFA	Neuropeptide Y Receptor
Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC₅₀=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca²⁺. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist.

HY-P1601

Neuropeptide Y(29-64)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

Neuropeptide Y(29-64)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

HY-P1438A

Neuropeptide S(Rat) TFA	Neuropeptide Y Receptor
Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC₅₀=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.

HY-P1246

Neuropeptide AF (human)
Neuropeptide AF (93-110), human
Opioid Receptor Neurological Disease

Neuropeptide AF (human) is an endogenous antiopioid peptide.

Neuropeptide AF (human) Neuropeptide AF (93-110), human	Opioid Receptor	Neurological Disease
Neuropeptide AF (human) is an endogenous antiopioid peptide.

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor.

HY-P1249

Neuropeptide SF(mouse,rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction.

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease.

HY-P1249A

Neuropeptide SF(mouse,rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P3679

Neuropeptide Y (1-24) (human)	Neuropeptide Y Receptor
Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.

HY-P0212

Neuropeptide Y, porcine
GCGR Metabolic Disease

Neuropeptide Y, porcine, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

Neuropeptide Y, porcine	GCGR	Metabolic Disease
Neuropeptide Y, porcine, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-P0198

Neuropeptide Y (human)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P0212A

Neuropeptide Y, porcine TFA
GCGR Metabolic Disease

Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

Neuropeptide Y, porcine TFA	GCGR	Metabolic Disease
Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

HY-P0198A

Neuropeptide Y (human) (TFA)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-144603

Neuropeptide Y Y1 receptor antagonist 1	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y¹ receptor (Y¹R), with a K_i of 0.19 nM. Storage: protect from light.

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1250A

RFRP-3(human) TFA Neuropeptide VF(124-131)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1723

Spexin Neuropeptide Q	Neuropeptide Y Receptor	Neurological Disease
Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin peptide contains numerous aromatic amino acids and is probably amidated.

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor
Spexin TFA is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Spexin TFA exhibits no significant activity at galanin receptor 1. Spexin TFA is an endogenous satiety-inducing peptide; Spexin TFA inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Spexin TFA attenuates LH secretion in goldfish. Spexin TFA exhibits anxiolytic effects in vivo.

HY-P3069

*γ-Neuropeptide* (rabbit)**	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-P1322

*[D-Trp34]-Neuropeptide* Y**	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.

HY-P1322A

*[D-Trp34]-Neuropeptide* Y TFA**	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.

HY-P1323

*[Leu31,Pro34]-Neuropeptide* Y(human,rat)**	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.

HY-P0198B

*[D-Arg25]-Neuropeptide* Y (human)**	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1323A

*[Leu31,Pro34]-Neuropeptide* Y(human,rat) TFA**	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

HY-P0208

*[Leu31,Pro34]-Neuropeptide* Y (porcine)**	Neuropeptide Y Receptor	Neurological Disease
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-P3885

Substance P (alligator)	Neurokinin Receptor Endogenous Metabolite	Neurological Disease
Substance P (alligator), a Substance P (Substance P (HY-P0201)) extracted from alligator, is a neuropeptide. The primary structure of Substance P (alligator) is: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

HY-P2278

PEN (human)	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

HY-P3576

*Biotin-Gastrin Releasing Peptide, human*	Fluorescent Dye	Cancer Neurological Disease
Biotin-Gastrin Releasing Peptide, human is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties.

HY-117541

Glycyl-glutamine Glycyl-L-glutamine	Others	Neurological Disease
Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln).

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor.

HY-P3839

Nocistatin	Opioid Receptor	Neurological Disease
Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a G_i/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.

HY-107726A

BIBP3226	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.

HY-107726

BIBP3226 TFA	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.

HY-P3922

[Gly11] Substance P	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P3925

[His11]Substance P	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist.

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.

HY-107731

SF 11
Neuropeptide Y Receptor Neurological Disease

SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC₅₀=199 nM). Antidepressant-like activity.

HY-P1304

CART(55-102)(human)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y.

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior.

HY-P1298

Sauvagine	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P1298A

Sauvagine TFA	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P0252A

α-MSH TFA α-Melanocyte-Stimulating Hormone TFA	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P3927

[MePhe8,Sar9] Substance P [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P1304A

CART(55-102)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) TFA is a human satiety factor with potent appetite-suppressing activity. CART(55-102)(human) TFA is closely associated with leptin and neuropeptide Y.

HY-145837

Y1R probe-1	Neuropeptide Y Receptor	Cancer
Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease.

HY-P1296

Urocortin, rat Urocortin (Rattus norvegicus); Rat urocortin;	CRFR	Neurological Disease Endocrinology
Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively.

HY-P1303

CART(62-76)(human,rat)	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.

HY-P1303A

CART(62-76)(human,rat) TFA	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) TFA is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) TFA can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.

HY-P99019

Fremanezumab TEV-48125	CGRP Receptor	Neurological Disease
Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to *calcitonin gene-related peptide* (CGRP)*. CGRP is a 37-amino acid neuropeptide* involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research.

HY-P1296A

Urocortin, rat TFA Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA	CRFR	Endocrinology Neurological Disease
Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively.

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior.

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior.

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.

HY-P3035

Corazonin	G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species.

HY-108625

SHA 68	Neuropeptide Y Receptor	Neurological Disease
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC₅₀s of 22.0 and 23.8 nM for NPSR Asn¹⁰⁷ and NPSR Ile¹⁰⁷, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.

HY-P1542

Urotensin I Catostomus urotensin I	CRFR	Cardiovascular Disease Endocrinology
Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC₅₀s of 11.46, 9.36 and 9.85 for human CRF₁, human CRF₂ and rat CRF_2α receptors in CHO cells, and K_is of 0.4, 1.8, and 5.7 nM for hCRF₁, rCRF_2α and mCRF_2β receptors, respectively.

HY-P1542B

Urotensin I TFA Catostomus urotensin I TFA	CRFR	Endocrinology Cardiovascular Disease
Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC₅₀s of 11.46, 9.36 and 9.85 for human CRF₁, human CRF₂ and rat CRF_2α receptors in CHO cells, and K_is of 0.4, 1.8, and 5.7 nM for hCRF₁, rCRF_2α and mCRF_2β receptors, respectively.

HY-P3517

β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Endocrinology Neurological Disease
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.

HY-P3887

MLGFFQQPKPR-NH2
Neurokinin Receptor Neurological Disease

MLGFFQQPKPR-NH2 is a reversed Substance P peptide. Substance P is a neuropeptide.

HY-P0250

Kassinin	Neurokinin Receptor	Neurological Disease Endocrinology
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P3888

Gly-Leu-Met-NH2
Neurokinin Receptor Neurological Disease

Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (Substance P (HY-P0201)). Substance P is a neuropeptide.
HY-P0268

Myomodulin
Calcium Channel Potassium Channel Sodium Channel Neurological Disease

Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.

HY-P3876

*(Pro34)-Peptide* YY (human)**	Neuropeptide Y Receptor	Neurological Disease
(Pro34)-Peptide YY (human) is a highly Y₁-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

HY-103277

BIM 23042	Bombesin Receptor	Metabolic Disease Neurological Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca²⁺ release.

HY-100921

Spaglumic Acid N-Acetylaspartylglutamic acid	Endogenous Metabolite	Neurological Disease
Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.

HY-14423

Velneperit
S2367
Neuropeptide Y Receptor Metabolic Disease Endocrinology

Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.
HY-P1499

Somatostatin-28 (1-14)
Somatostatin Receptor Neurological Disease

Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.
HY-U00335

FR252384
Neuropeptide Y Receptor Endocrinology

FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC₅₀ of 2.3 nM.
HY-101704

Y1 receptor antagonist 1
H 409-22 isomer
Neurokinin Receptor Neurological Disease Endocrinology

Y1 receptor antagonist 1 (H 409-22 isomer) is a neuropeptide Y1 receptor antagonist.
HY-15411

MK-0557
Neuropeptide Y Receptor Metabolic Disease Endocrinology

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K_i of 1.6 nM.

HY-P0002A

Protirelin acetate Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Endocrinology Inflammation/Immunology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P2277

PEN (rat)	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

HY-101986

BIIE-0246 AR-H 053591	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
BIIE-0246 is a potent and highly selective *non-peptide* neuropeptide Y (NPY) Y₂ receptor antagonist, with an IC₅₀** of 15 nM.

HY-107735

CYM 9484
Neuropeptide Y Receptor Neurological Disease

CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC₅₀ value of 19 nM.

HY-P1127

Galanin (1-30), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-107733

NTNCB hydrochloride	Neuropeptide Y Receptor	Neurological Disease
NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a K_i of 8 nM against human Y5.

HY-107382

RF9	Neuropeptide Y Receptor	Endocrinology Neurological Disease Cardiovascular Disease
RF9 is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

HY-107382A

RF9 hydrochloride	Neuropeptide Y Receptor	Endocrinology Neurological Disease Cardiovascular Disease
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-107723

CGP71683 hydrochloride CGP71683A	Neuropeptide Y Receptor	Neurological Disease Endocrinology
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K_i of 1.3 nM, and shows no obvious activity at Y1 receptor (K_i, >4000 nM) and Y2 receptor (K_i, 200 nM) in cell membranes.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-107728

S 25585	Neuropeptide Y Receptor	Metabolic Disease
S 25585 is a potent and selective neuropeptide Y (NPY) Y5 receptor antagonist. S 25585 reduces food intake but not through blockade of the NPY Y5 receptor.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-111308

RTI-118	Neuropeptide Y Receptor	Neurological Disease
RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration.

HY-107729

Lu AA33810	Neuropeptide Y Receptor	Neurological Disease
Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a K_i of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.

HY-P1485

Substance P(1-7)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

HY-P1594

Dynorphin A (1-10)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P1071

α-CGRP(human)	CGRP Receptor	Cardiovascular Disease
α-CGRP(human) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator.

HY-P1485A

Substance P(1-7) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P1071A

α-CGRP(human) TFA	CGRP Receptor	Cardiovascular Disease
α-CGRP(human) TFA is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) TFA is a potent vasodilator.

HY-P1295

Urocortin, human Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I	CRFR	Neurological Disease Endocrinology
Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF₂ receptor, with K_is of 0.4, 0.3, and 0.5 nM for hCRF₁, rCRF_2α and mCRF_2β, respectively.

HY-P3897

[Tyr12] Somatostatin 28 (1-14)	Somatostatin Receptor	Neurological Disease
[Tyr12] Somatostatin 28 (1-14) is an analogue of Somatostatin-28 (1-14) (HY-P1499). Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-P3845

(Gly22)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1132

Galanin (1-29)(rat, mouse)	Neuropeptide Y Receptor	Neurological Disease
Galanin (1-29)(rat, mouse) is a non-selective galanin receptor agonist, with K_is of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively. Anticonvulsant effect.

HY-P1341

OXA(17-33)	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P1341A

OXA(17-33) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P3846

(Glu20)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease.

HY-P4815

Prokineticin 2 Isoform 2 (human)	Endogenous Metabolite	Metabolic Disease Neurological Disease
Prokineticin 2 Isoform 2 (human) is a hypothalamic neuropeptide. Prokineticin 2 Isoform 2 (human) decreases food intake and involves in thermoregulation and energy metabolism in rodents. Prokineticin 2 has the potential for the research of hyperglycemia, metabolic syndrome (MetS) and obesity.

HY-107725

BIBO3304 TFA	Neuropeptide Y Receptor	Metabolic Disease
BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC₅₀=0.38 and 0.72 nM, respectively).

HY-P3880

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P (HY-P0201) antagonist.

HY-P0252

α-MSH α-Melanocyte-Stimulating Hormone	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-107734

L 152804	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

HY-14450

JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease Endocrinology
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC₅₀ values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-108624

CYM 50769	Others	Inflammation/Immunology Cardiovascular Disease
CYM 50769 is a non-peptidic selective antagonist of neuropeptides B and W receptor 1 (NPBWR1). CYM 50769 can attenuates the NPW-23-induced cell proliferation in ATDC5. CYM 50769 can be used for researching endochondral bone formation.

HY-P1302A

Orphanin FQ(1-11) TFA	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a K_i of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice.

HY-P1302

Orphanin FQ(1-11)	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a K_i of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice.

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus.

HY-P1932

Cortistatin-14	Somatostatin Receptor	Inflammation/Immunology Neurological Disease Endocrinology
Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1932A

Cortistatin-14 TFA	Somatostatin Receptor	Inflammation/Immunology Neurological Disease Endocrinology
Cortistatin-14 (TFA), a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.

HY-120619

BMS-193885	Neuropeptide Y Receptor	Neurological Disease Endocrinology
BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y₁ receptor antagonist with a K_i of 3.3 nM, and has an IC₅₀ of 5.9 nM for hY₁, which displays > 100, > 160, > 160 and > 160-fold selectivity over α₁, hY₂, hY₄ and hY₅ receptors, respectively .

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P0203

α-CGRP, rat	CGRP Receptor	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
α-CGRP, rat, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP, rat can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP, rat has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

HY-P1428

RFRP-1(human)	Neuropeptide Y Receptor	Endocrinology
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively.

HY-P3618

Cortistatin 29	Somatostatin Receptor	Neurological Disease
Cortistatin 29 is a neuropeptide. Cortistatin 29 alleviates neuropathic pain. Cortistatin 29 binds with high affinity all somatostatin (SS) receptor subtypes and shows IC₅₀ values of 2.8, 7.1, 0.2, 3.0, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin 29 shows anti-fibrotic effects.

HY-14407

Fosaprepitant L-758298	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-14407A

Fosaprepitant dimeglumine MK-0517; L785298	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-P1840A

Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	Endocrinology Neurological Disease
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

HY-P0203A

α-CGRP, rat TFA	CGRP Receptor	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
α-CGRP, rat TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP, rat TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP, rat TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

HY-P0049A

Argipressin diacetate Arg8-vasopressin diacetate; AVP diacetate; ADH	Apoptosis Vasopressin Receptor	Neurological Disease
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

HY-106224

Orexin A (human, rat, mouse) Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-101986A

BIIE-0246 hydrochloride AR-H 053591 hydrochloride	Neuropeptide Y Receptor	Metabolic Disease
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective *NPY2R (neuropeptide* Y receptor 2) antagonist with an IC₅₀** value of 15 nM for rat [¹²⁵I]PYY_3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.

HY-106224B

Orexin A (human, rat, mouse) (acetate) Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate is also an OX1R agonist that induces the expression of BDNF and TH proteins in SH-SY5Y cells in a time- and dose-dependent manner. Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-107732

JNJ-5207787	Neuropeptide Y Receptor	Neurological Disease
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y₂ receptor (Y₂) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC₅₀s of 7.0 and 7.1 for human Y₂ receptor and rat Y₂ receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y₁, Y₄, and Y₅ receptors.

HY-P3467

(Thr4,Gly7)-Oxytocin	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K⁺ channels. .

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels.

HY-106224A

Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-107479

(R)-JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC₅₀ values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.

HY-110220

CIM0216	TRP Channel	Neurological Disease
CIM0216, a synthetic TRPM3 ligand, acts as a potent and selective agonist of TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts in a TRPM3-dependent manner to induce pain and evoke neuropeptide release from sensory nerve terminals in vitro. CIM0216 is a powerful tool for studies of the physiological functions of TRPM3, and can be used for neurogenic inflammation research.

HY-15114

S 17092 S 17092-1	Prolyl Endopeptidase (PREP)	Neurological Disease
S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC₅₀ of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging.

HY-P1324A

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P1324

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-147859

BChE-IN-8	Amyloid-β	Neurological Disease
BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC₅₀ values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research.

HY-P1840

Galanin Receptor Ligand M35	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

HY-103247

EMD 66684	Angiotensin Receptor	Cardiovascular Disease
EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant ^-.

Cat. No.	Product Name	Type

HY-144603

Neuropeptide Y Y1 receptor antagonist 1	Fluorescent Dyes/Probes
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y¹ receptor (Y¹R), with a K_i of 0.19 nM. Storage: protect from light.

Cat. No.	Product Name	Target	Research Area

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC₅₀ values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.

HY-P1389

Neuropeptide S (human)	Peptides	Neurological Disease
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.

HY-P1389A

Neuropeptide S (human) (TFA)	Peptides	Neurological Disease
Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research.

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀ of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.

HY-P1035

Neuropeptide W-23 (human) NPW-23	Peptides	Neurological Disease
Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.

HY-P3678

Neuropeptide Y (18-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC₅₀ value of 158 nM and an K_i value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.

HY-P1035A

Neuropeptide W-23 (human) (TFA) NPW-23 TFA	Peptides	Neurological Disease
Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

HY-P1437A

Neuropeptide S(Mouse) TFA	Neuropeptide Y Receptor
Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC₅₀=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca²⁺. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist.

HY-P1601

Neuropeptide Y(29-64)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

HY-P1438A

Neuropeptide S(Rat) TFA	Neuropeptide Y Receptor
Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC₅₀=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.

HY-P1246

Neuropeptide AF (human)
Neuropeptide AF (93-110), human
Opioid Receptor Neurological Disease

Neuropeptide AF (human) is an endogenous antiopioid peptide.

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor.

HY-P3873

Neuropeptide FF (5-8)	Peptides	Neurological Disease
Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a K_i value of 20.9 nM.

HY-P1249

Neuropeptide SF(mouse,rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction.

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease.

HY-P1249A

Neuropeptide SF(mouse,rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P3679

Neuropeptide Y (1-24) (human)	Neuropeptide Y Receptor
Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.

HY-P0212

Neuropeptide Y, porcine
GCGR Metabolic Disease

Neuropeptide Y, porcine, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-P0198

Neuropeptide Y (human)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P0212A

Neuropeptide Y, porcine TFA
GCGR Metabolic Disease

Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

HY-P0198A

Neuropeptide Y (human) (TFA)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1248

Neuropeptide FF NPFF	Peptides	Cardiovascular Disease
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation.

HY-P4765

Neuropeptide Y-Lys(biotinyl) free acid (human, rat)	Peptides	Others
Neuropeptide Y-Lys(biotinyl) (free acid) (human, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1250A

RFRP-3(human) TFA Neuropeptide VF(124-131)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor
Spexin TFA is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Spexin TFA exhibits no significant activity at galanin receptor 1. Spexin TFA is an endogenous satiety-inducing peptide; Spexin TFA inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Spexin TFA attenuates LH secretion in goldfish. Spexin TFA exhibits anxiolytic effects in vivo.

HY-P3844

*Biotinyl-neuropeptide* W-23 (human)**	Peptides	Neurological Disease
Biotinyl-neuropeptide W-23 (human) is a biotinylated neuropeptide W-23 (human) (HY-P1035). Neuropeptide W-23 (human) is an agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

HY-P3840

Head activator neuropeptide	Peptides	Cancer Neurological Disease
Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis.

HY-P3069

*γ-Neuropeptide* (rabbit)**	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-P1322

*[D-Trp34]-Neuropeptide* Y**	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.

HY-P1322A

*[D-Trp34]-Neuropeptide* Y TFA**	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.

HY-P1323

*[Leu31,Pro34]-Neuropeptide* Y(human,rat)**	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.

HY-P0198B

*[D-Arg25]-Neuropeptide* Y (human)**	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1323A

*[Leu31,Pro34]-Neuropeptide* Y(human,rat) TFA**	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

HY-P0208

*[Leu31,Pro34]-Neuropeptide* Y (porcine)**	Neuropeptide Y Receptor	Neurological Disease
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P4807

*Pheromone Biosynthesis Activating Neuropeptide* (Helicoverpa assulta, Heliothis zea)** Hez-PBAN	Peptides	Neurological Disease
Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (PBAN), a member of the PBAN/Pyrokinin neuropeptide family, characterized by a common amino acid sequence FXPRLamide motif in the C-terminus.

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-P4414

*(Des-Bromo)-Neuropeptide* B (1-23) (human)**	Peptides	Neurological Disease
(Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with K_is of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively.

HY-P3885

Substance P (alligator)	Neurokinin Receptor Endogenous Metabolite	Neurological Disease
Substance P (alligator), a Substance P (Substance P (HY-P0201)) extracted from alligator, is a neuropeptide. The primary structure of Substance P (alligator) is: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

HY-P3591

YMRF-NH2
Peptides Neurological Disease

YMRF-NH2 is a neuropeptide. YMRF-NH2 binds to FMRFa-R with an EC₅₀ value of 31 nM.

HY-P3576

*Biotin-Gastrin Releasing Peptide, human*	Fluorescent Dye	Cancer Neurological Disease
Biotin-Gastrin Releasing Peptide, human is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties.

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor.

HY-P3839

Nocistatin	Opioid Receptor	Neurological Disease
Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a G_i/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.

HY-P1239

Neuromedin S(rat)	Peptides	Neurological Disease
Neuromedin S(rat) is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P3631

SALMF amide 2	Peptides	Neurological Disease
SALMF amide 2, a neuropeptide S2 from the starfish Asterias rubens, is involved in the regulation of eversion of the cardiac stomach in starfish.

HY-P1239A

Neuromedin S(rat) TFA	Peptides	Neurological Disease
Neuromedin S(rat) TFA is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P3922

[Gly11] Substance P	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P3925

[His11]Substance P	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P4058

Calcitonin gene-related peptide CGRP	Peptides	Neurological Disease
Calcitonin gene-related peptide (CGRP) is a neuropeptide. Calcitonin gene-related peptide can be used for the research of nociception, ingestive behaviour and modulation of the endocrine systems.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist.

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.

HY-P3712

*Cardioexcitatory peptide* 1**	Peptides	Neurological Disease Cardiovascular Disease
Cardioexcitatory peptide 1 is a cardioexcitatory neuropeptide, can be isolated from Achatina atria. Cardioexcitatory peptide 1 has potent cardio-excitatory action on the hearts and also modifies the motility of muscular tissues and neural activities.

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.

HY-P1304

CART(55-102)(human)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y.

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior.

HY-P1298

Sauvagine	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P1298A

Sauvagine TFA	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P0252A

α-MSH TFA α-Melanocyte-Stimulating Hormone TFA	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P3927

[MePhe8,Sar9] Substance P [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.

HY-P3633

Locustatachykinin II Lom-TK II	Peptides	Neurological Disease
Locustatachykinin II (Lom-TK II) is an insect neuropeptide with homology to peptides of the vertebrate tachykinin family. Locustatachykinin II can be used for the research of insect endocrine.

HY-P3848

Tyr0-Neurokinin A	Peptides	Metabolic Disease Neurological Disease
Tyr0-Neurokinin A is a neuropeptide belongs to tachykinin peptide family. Tyr0-Neurokinin A is an agonist of Tacr2. Tyr0-Neurokinin A can be used in the research of insulin resistance, obesity, diabetes.

HY-P1304A

CART(55-102)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) TFA is a human satiety factor with potent appetite-suppressing activity. CART(55-102)(human) TFA is closely associated with leptin and neuropeptide Y.

HY-P1296

Urocortin, rat Urocortin (Rattus norvegicus); Rat urocortin;	CRFR	Neurological Disease Endocrinology
Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively.

HY-P3050

Helospectin II	Peptides	Cardiovascular Disease
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.

HY-P1303

CART(62-76)(human,rat)	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.

HY-P1303A

CART(62-76)(human,rat) TFA	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) TFA is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) TFA can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.

HY-P1296A

Urocortin, rat TFA Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA	CRFR	Endocrinology Neurological Disease
Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively.

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior.

HY-P3053

Helospectin I	Peptides	Cardiovascular Disease
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior.

HY-P3635

*Cockroach Myoactive Peptide* II** Pea-CAH-II	Peptides	Metabolic Disease Neurological Disease
Cockroach Myoactive Peptide II (Pea-CAH-II) is a cockroach *neuropeptide. Cockroach Myoactive Peptide* II is a member of the adipokinetic hormone/red pigment concentrating hormone (AKH/RPCH) family. Cockroach Myoactive Peptide II can be used for the research of metabolic functions of insect body.

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.

HY-P3035

Corazonin	G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species.

HY-P2042

SALMF amide 1
Peptides Neurological Disease

SALMF amide 1 is a neuropeptide.

HY-P1542

Urotensin I Catostomus urotensin I	CRFR	Cardiovascular Disease Endocrinology
Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC₅₀s of 11.46, 9.36 and 9.85 for human CRF₁, human CRF₂ and rat CRF_2α receptors in CHO cells, and K_is of 0.4, 1.8, and 5.7 nM for hCRF₁, rCRF_2α and mCRF_2β receptors, respectively.

HY-P1542B

Urotensin I TFA Catostomus urotensin I TFA	CRFR	Endocrinology Cardiovascular Disease
Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC₅₀s of 11.46, 9.36 and 9.85 for human CRF₁, human CRF₂ and rat CRF_2α receptors in CHO cells, and K_is of 0.4, 1.8, and 5.7 nM for hCRF₁, rCRF_2α and mCRF_2β receptors, respectively.

HY-P3517

β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Endocrinology Neurological Disease
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.

HY-P2183

PEN(mouse)
proSAAS(221-242)
Peptides Neurological Disease

PEN(mouse) (proSAAS(221-242)) is the precursor of a number of peptides that function as neuropeptides.
HY-P3887

MLGFFQQPKPR-NH2
Neurokinin Receptor Neurological Disease

MLGFFQQPKPR-NH2 is a reversed Substance P peptide. Substance P is a neuropeptide.

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Peptides	Neurological Disease Cardiovascular Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.

HY-P2183A

PEN(mouse) TFA
proSAAS(221-242) TFA
Peptides Neurological Disease

PEN(mouse) TFA (proSAAS(221-242) TFA) is the precursor of a number of peptides that function as neuropeptides.

HY-P0250

Kassinin	Neurokinin Receptor	Neurological Disease Endocrinology
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P3888

Gly-Leu-Met-NH2
Neurokinin Receptor Neurological Disease

Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (Substance P (HY-P0201)). Substance P is a neuropeptide.
HY-P0268

Myomodulin
Calcium Channel Potassium Channel Sodium Channel Neurological Disease

Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.

HY-P3876

*(Pro34)-Peptide* YY (human)**	Neuropeptide Y Receptor	Neurological Disease
(Pro34)-Peptide YY (human) is a highly Y₁-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

HY-P1915

*26Rfa, Hypothalamic Peptide, human*	Peptides	Metabolic Disease
26Rfa, Hypothalamic Peptide, human is a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. 26RFa is an orexigenic neuropeptide identified as the endogenous ligand of the orphan G protein-coupled receptor GPR103.

HY-P0194

NocII
Peptides Neurological Disease

NocII is an orphan neuropeptide which stimulates locomotion in mice.
HY-P1501

δ-Sleep Inducing Peptide
Delta-Sleep Inducing Peptide
Peptides Neurological Disease

δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
HY-P0194A

NocII TFA
Peptides Neurological Disease

NocII TFA is an orphan neuropeptide which stimulates locomotion in mice.
HY-P2169

Small cardioactive peptide A
SCPA
Peptides Neurological Disease

Small cardioactive peptide A (SCPA) is a neuropeptide that can be obtained from Aplysia.
HY-P1499

Somatostatin-28 (1-14)
Somatostatin Receptor Neurological Disease

Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.

HY-P1501A

*δ-Sleep Inducing Peptide* acetate** Delta-Sleep Inducing Peptide acetate	Peptides	Neurological Disease
δ-Sleep Inducing Peptide acetate is a neuropeptide, with antioxidant and anxiolytic properties.

HY-P1547

Somatostatin-25
Peptides Neurological Disease

Somatostatin-25 is a endogenous neuropeptide hormone that shows inhibitory activity against secretion of growth hormone.
HY-P4806

Perisulfakinin
Peptides Neurological Disease

Perisulfakinin, a satiety signaling neuropeptide, inhibits the activity of central neurons promoting general activity.
HY-P1760

Allatostatin IV
Peptides Neurological Disease

Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.
HY-P1786

Allatostatin II
Peptides Neurological Disease

Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.

HY-P1882

Type A Allatostatin I	Peptides	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.

HY-P0002A

Protirelin acetate Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Endocrinology Inflammation/Immunology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P2277

PEN (rat)	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

HY-P1127

Galanin (1-30), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-P3636

*Cockroach Myoactive Peptide* I** Pea-CAH-I	Peptides	Neurological Disease
Cockroach Myoactive Peptide I (Pea-CAH-I) is a cockroach neuropeptide, a member of the adipokinetic hormone/red pigment-concentrating hormone family (AKH/RPCH family).

HY-P4904

RFRP-3 (rat)	Peptides	Neurological Disease
RFRP-3 (rat) is a neuropeptide. RFRP-3 (rat) inhibits gonadotropin secretion, causing a marked increase in ghrelin mRNA and plasma growth hormone levels.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1485

Substance P(1-7)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

HY-P1594

Dynorphin A (1-10)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P1765

Galanin (1-19), human	Peptides	Neurological Disease
Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior.

HY-P1071

α-CGRP(human)	CGRP Receptor	Cardiovascular Disease
α-CGRP(human) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator.

HY-P1485A

Substance P(1-7) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P1071A

α-CGRP(human) TFA	CGRP Receptor	Cardiovascular Disease
α-CGRP(human) TFA is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) TFA is a potent vasodilator.

HY-P1295

Urocortin, human Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I	CRFR	Neurological Disease Endocrinology
Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF₂ receptor, with K_is of 0.4, 0.3, and 0.5 nM for hCRF₁, rCRF_2α and mCRF_2β, respectively.

HY-P3897

[Tyr12] Somatostatin 28 (1-14)	Somatostatin Receptor	Neurological Disease
[Tyr12] Somatostatin 28 (1-14) is an analogue of Somatostatin-28 (1-14) (HY-P1499). Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.

HY-P1732

Transportan	Peptides	Cancer
Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan belongs to cell-penetrating peptides (CPPs).

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-P3845

(Gly22)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1341

OXA(17-33)	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

HY-P1341A

OXA(17-33) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P3846

(Glu20)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease.

HY-P4815

Prokineticin 2 Isoform 2 (human)	Endogenous Metabolite	Metabolic Disease Neurological Disease
Prokineticin 2 Isoform 2 (human) is a hypothalamic neuropeptide. Prokineticin 2 Isoform 2 (human) decreases food intake and involves in thermoregulation and energy metabolism in rodents. Prokineticin 2 has the potential for the research of hyperglycemia, metabolic syndrome (MetS) and obesity.

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa*	Peptides	Neurological Disease
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.

HY-P3880

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P (HY-P0201) antagonist.

HY-P0252

α-MSH α-Melanocyte-Stimulating Hormone	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P3826

Chromogranin A (324-337), human	Peptides	Neurological Disease
Chromogranin A (324-337), human is a peptide fragment of chromogranin A, it can be isolated from human ileal carcinoid tumor. Chromogranin A is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules of most (neuro)endocrine cells and neurons, and it is also a plasma marker of neuroendocrine tumors.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P2210A

BigLEN(mouse) TFA	Peptides
BigLEN(mouse) TFA is a GPR171 agonist. BigLEN(mouse) TFA is a proSAAS-derived neuropeptide. BigLEN(mouse) TFA regulates food intake in mice. BigLEN(mouse) inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

HY-P1302A

Orphanin FQ(1-11) TFA	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a K_i of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice.

HY-P1302

Orphanin FQ(1-11)	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a K_i of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice.

HY-P0221

PACAP (1-38), human, ovine, rat Pituitary Adenylate Cyclase Activating Polypeptide 38	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus.

HY-P1932

Cortistatin-14	Somatostatin Receptor	Inflammation/Immunology Neurological Disease Endocrinology
Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.

HY-P1833

Egg Laying Hormone, aplysia	Peptides	Neurological Disease
Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron.

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1932A

Cortistatin-14 TFA	Somatostatin Receptor	Inflammation/Immunology Neurological Disease Endocrinology
Cortistatin-14 (TFA), a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3593

LPLRF-NH2	Peptides	Neurological Disease Cardiovascular Disease
LPLRF-NH2 is a member of RFamide peptide with anorexigenic effect. LPLRF-NH2 increases arterial blood pressure and modulates the electrical activity of brainstem neurons.

HY-P3778

γ-Bag cell peptide	Peptides	Neurological Disease
γ-bag cell peptide is a *peptide. γ-bag cell peptide* is located near the N-terminus of the egg laying prohormone, the vesicle is released upon insulin stimulation. γ-bag cell peptide can be used for the research of the central and peripheral nervous systems.

HY-P2472

Orphan GPCR SP9155 agonist P550 (mouse, rat) 26RFa (mouse, rat)	Peptides	Metabolic Disease
Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27.

HY-P0203

α-CGRP, rat	CGRP Receptor	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
α-CGRP, rat, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP, rat can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP, rat has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

HY-P1428

RFRP-1(human)	Neuropeptide Y Receptor	Endocrinology
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively.

HY-P3618

Cortistatin 29	Somatostatin Receptor	Neurological Disease
Cortistatin 29 is a neuropeptide. Cortistatin 29 alleviates neuropathic pain. Cortistatin 29 binds with high affinity all somatostatin (SS) receptor subtypes and shows IC₅₀ values of 2.8, 7.1, 0.2, 3.0, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin 29 shows anti-fibrotic effects.

HY-P1840A

Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	Endocrinology Neurological Disease
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

HY-P0203A

α-CGRP, rat TFA	CGRP Receptor	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
α-CGRP, rat TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP, rat TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP, rat TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

HY-P0049A

Argipressin diacetate Arg8-vasopressin diacetate; AVP diacetate; ADH	Apoptosis Vasopressin Receptor	Neurological Disease
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

HY-106224

Orexin A (human, rat, mouse) Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224B

Orexin A (human, rat, mouse) (acetate) Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate is also an OX1R agonist that induces the expression of BDNF and TH proteins in SH-SY5Y cells in a time- and dose-dependent manner. Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-P3467

(Thr4,Gly7)-Oxytocin	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K⁺ channels. .

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels.

HY-106224A

Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P1324A

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P1324

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P1840

Galanin Receptor Ligand M35	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

Cat. No.	Product Name	Target	Research Area

HY-P99019

Fremanezumab TEV-48125	CGRP Receptor	Neurological Disease
Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to *calcitonin gene-related peptide* (CGRP)*. CGRP is a 37-amino acid neuropeptide* involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research.

Cat. No.	Product Name	Target	Category

HY-P0250

Kassinin	Neurokinin Receptor	Natural Products Classification of Application Fields Disease Research Fields Endocrinology Neurological Disease Source classification Animals
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P0268

Myomodulin
Calcium Channel Potassium Channel Sodium Channel Natural Products Source classification Animals

Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.

HY-100921

Spaglumic Acid N-Acetylaspartylglutamic acid	Endogenous Metabolite	Ketones, Aldehydes, Acids Source classification Endogenous metabolite
Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Neurological Disease Disease Research Fields Classification of Application Fields Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa*	Others	Natural Products Source classification Animals
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.

Species:	Human (3)
Tag:	His (1) GST (2)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Product Name	Species	Source

HY-P71449

Neuropeptide B Protein, Human (GST)
NPB; PPL7; PPNPB; Neuropeptide B; Neuropeptide B-29; NPB29;
Human E. coli
HY-P71063

NPY Protein, Human (HEK293, His)
Pro-Neuropeptide Y; Neuropeptide Y; Neuropeptide Tyrosine; NPY; C-Flanking Peptide of NPY; CPON; NPY
Human HEK293

HY-P72160

CXCR4 Protein, Human (GST) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS	Human	E. coli

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