LPLRF-NH2
LPLRF-NH2 is a member of RFamide peptide with anorexigenic effect. LPLRF-NH2 increases arterial blood pressure and modulates the electrical activity of brainstem neurons.
For research use only. We do not sell to patients.
- CAS No.: 88280-21-1
- Formula: C32H53N9O5
- Molecular Weight:643.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
YMRF-NH2 (0.1 nM-1 μM) inhibits Forskolin-induced production of cAMP in CHO cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LPLRF-NH2 (25-50 nM/kg, 150 μL, i.v.) increases arterial blood pressure in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Chicks[1]
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Dosage:3.0, 7.0 or 15 nmol
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Administration:Intracerebroventrical injection (ICV) injection
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Result:Decreased food intake.
Increased number of c-Fos reactive cells in the paraventricular nucleus.
Chemical Information
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CAS No. 88280-21-1
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Molecular Weight 643.82
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Formula C32H53N9O5
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Sequence Shortening
LPLRF-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Scheel A, et al. LPLRFamide exerts short-term anorexigenic effects that coincide with magnocellular division of the hypothalamic paraventricular nucleus activation. Gen Comp Endocrinol. 2017 May 15;246:116-119. [Content Brief]
[2]. Barnard CS, et al. Increases in arterial blood pressure in the rat in response to a new vertebrate neuropeptide, LPLRFamide, and a related molluscan peptide, FMRFamide. Regul Pept. 1984 Apr;8(3):209-15. [Content Brief]
[3]. Chartrel N, et al. Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates. Peptides. 2006 May;27(5):1110-20. [Content Brief]
[4]. Hinuma S, et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol. 2000 Oct;2(10):703-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LPLRF-NH2 Related Classifications
HY-P3593 Related Classifications
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