New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

  • Nat Cell Biol. 2000 Oct;2(10):703-8. doi: 10.1038/35036326.
S Hinuma  1 ,  Y Shintani ,  S Fukusumi ,  N Iijima ,  Y Matsumoto ,  M Hosoya ,  R Fujii ,  T Watanabe ,  K Kikuchi ,  Y Terao ,  T Yano ,  T Yamamoto ,  Y Kawamata ,  Y Habata ,  M Asada ,  C Kitada ,  T Kurokawa ,  H Onda ,  O Nishimura ,  M Tanaka ,  Y Ibata ,  M Fujino
Affiliations
  • 1. Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd., 10 Wadai, Tsukuba, Ibaraki 300-4293, Japan.
PMID: 11025660 DOI: 10.1038/35036326
Abstract

Only a few RFamide Peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related Peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases Prolactin secretion in rats. Our results indicate that a variety of RFamide-related Peptides may exist and function in mammals.

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