(Thr4,Gly7)-Oxytocin
Based on 3 publication(s) in Google Scholar
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. .
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 60786-59-6
- Formula: C39H61N11O12S2
- Molecular Weight:940.10
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) (Thr4,Gly7)-Oxytocin
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Biological Activity
OT receptors, K+ channels[1].
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons[1].
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons[1].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells[2].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster mice [1]
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Dosage:1 μM
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Administration:Intratracheal administration for 24 h
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Result:Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
Chemical Information
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CAS No. 60786-59-6
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Appearance Solid
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Molecular Weight 940.10
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Formula C39H61N11O12S2
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Neuron
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265 -
Curr Biol
Reduced oxytocin signaling in the dBNST drives the transition from acute pain to persistent anxiety. [Abstract]2025 Sep 26:S0960-9822(25)01182-0. PMID: 41015042 -
Neuropharmacology
Oxytocin receptors within the caudal lateral septum regulate social approach-avoidance, long-term social discrimination, and anxiety-like behaviors in adult male and female rats. [Abstract]2025 Jun 15:271:110409. PMID: 40074168
Solvent & Solubility
DMSO : ≥ 100 mg/mL (106.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (53.19 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [Content Brief]
[2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. [Content Brief]
[3]. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.0637 mL | 5.3186 mL | 10.6372 mL | 26.5929 mL |
| 5 mM | 0.2127 mL | 1.0637 mL | 2.1274 mL | 5.3186 mL | |
| 10 mM | 0.1064 mL | 0.5319 mL | 1.0637 mL | 2.6593 mL | |
| 15 mM | 0.0709 mL | 0.3546 mL | 0.7091 mL | 1.7729 mL | |
| 20 mM | 0.0532 mL | 0.2659 mL | 0.5319 mL | 1.3296 mL | |
| 25 mM | 0.0425 mL | 0.2127 mL | 0.4255 mL | 1.0637 mL | |
| 30 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.8864 mL | |
| 40 mM | 0.0266 mL | 0.1330 mL | 0.2659 mL | 0.6648 mL | |
| 50 mM | 0.0213 mL | 0.1064 mL | 0.2127 mL | 0.5319 mL | |
| DMSO | 60 mM | 0.0177 mL | 0.0886 mL | 0.1773 mL | 0.4432 mL |
| 80 mM | 0.0133 mL | 0.0665 mL | 0.1330 mL | 0.3324 mL | |
| 100 mM | 0.0106 mL | 0.0532 mL | 0.1064 mL | 0.2659 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(Thr4,Gly7)-Oxytocin Related Classifications
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