1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Substance P (1-7)(TFA)

Substance P (1-7)(TFA) 

Cat. No.: HY-P1485A Purity: 99.20%
Handling Instructions

Substance P (1-7)(TFA) is a fragment of the neuropeptide, substance P (SP). Substance P (1-7)(TFA) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Substance P (1-7)(TFA) Chemical Structure

Substance P (1-7)(TFA) Chemical Structure

Size Price Stock Quantity
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Substance P (1-7)(TFA):

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Substance P (1-7)(TFA) is a fragment of the neuropeptide, substance P (SP). Substance P (1-7)(TFA) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

In Vivo

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2].

Molecular Weight






Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (49.31 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9861 mL 4.9307 mL 9.8613 mL
5 mM 0.1972 mL 0.9861 mL 1.9723 mL
10 mM 0.0986 mL 0.4931 mL 0.9861 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration


Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 μL), SP (0.007-0.7 nmol) or Substance P (1-7) (0.01-1 nmol) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 μL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1-7)[1].
The accumulated response time (s) of reciprocal movements of hindlimb scratching, biting, fore- and hindpaw licking are measured in Male mice (STD strain, 23-28 g) during the whole period of aversive response and 20 min at maximum. Substance P (1-7) is tested for its ability to inhibit the aversive response produced by intrathecal injection of SP or SP(5-11) (0.1 nM/mouse). Substance P (1-7) (1, 2, 4 pmol) is then administered together with SP or SP(5-11)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.20%

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Substance P (1-7)(TFA)Neurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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