Neuropeptide Y (18-36) (porcine)
Based on 1 Customer Validation
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.
For research use only. We do not sell to patients.
- Purity : 98.76%
- CAS No.: 114495-97-5
- Formula: C112H174N36O27
- Molecular Weight:2456.80
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Neuropeptide Y Receptor Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]
In Vitro
Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1].
Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1].
Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 114495-97-5
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Appearance Solid
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Molecular Weight 2456.80
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Formula C112H174N36O27
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Color White to off-white
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Sequence
Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
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Sequence Shortening
ARYYSALRHYINLITRQRY-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (40.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4070 mL | 2.0352 mL | 4.0703 mL | 10.1758 mL |
| 5 mM | 0.0814 mL | 0.4070 mL | 0.8141 mL | 2.0352 mL | |
| 10 mM | 0.0407 mL | 0.2035 mL | 0.4070 mL | 1.0176 mL | |
| 15 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.6784 mL | |
| 20 mM | 0.0204 mL | 0.1018 mL | 0.2035 mL | 0.5088 mL | |
| 25 mM | 0.0163 mL | 0.0814 mL | 0.1628 mL | 0.4070 mL | |
| 30 mM | 0.0136 mL | 0.0678 mL | 0.1357 mL | 0.3392 mL | |
| 40 mM | 0.0102 mL | 0.0509 mL | 0.1018 mL | 0.2544 mL |
Neuropeptide Y (18-36) (porcine) Related Classifications
HY-P3678 Related Classifications
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