1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RFRP-3(human)

RFRP-3(human) (Synonyms: Neuropeptide VF(124-131)(human))

Cat. No.: HY-P1250
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RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.

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RFRP-3(human) Chemical Structure

RFRP-3(human) Chemical Structure

CAS No. : 311309-27-0

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Description

RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].

In Vitro

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].
Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].
RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].

Molecular Weight

969.14

Formula

C₄₅H₇₂N₁₄O₁₀

CAS No.

311309-27-0

Sequence Shortening

VPNLPQRF-NH2

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Keywords:

RFRP-3(human)Neuropeptide VF(124-131)(human)Neuropeptide Y ReceptorNPY receptorHypothalamicPituitaryAxisLHFSHGnIHhomologInhibitorinhibitorinhibit

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RFRP-3(human)
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