BIM 23042
Based on 1 publication(s) in Google Scholar
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin?B?(HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release.
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- No. CAS: 111857-96-6
- Fòrmula: C63H73N11O9S2
- Peso molecular:1192.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-103286
PD176252BB1/BB2 Antagonist -
HY-103281
LitorinBombesin Receptor Agonist -
HY-P0195
BombesinBombesin Receptor Modulator -
HY-103286R
PD176252 (Standard)Reference Standard -
![[D-Phe12,Leu14]-Bombesin](https://file.medchemexpress.com/product_pic/hy-103287.gif)
HY-103287
[D-Phe12,Leu14]-BombesinBombesin Receptor Antagonist -
HY-P0238
Gastrin-Releasing Peptide, humanGastrin Releasing Peptide -
HY-P0241
Neuromedin BEndogenous Metabolite -
HY-101844
ML-18BRS-3 Antagonist -
HY-103285
GRP (porcine)Gastrin Release Stimulator -
HY-14342
MK-5046BRS-3 Agonist -
HY-103276
AlytesinBombesin-Like Peptide -
![[D-Phe12]-Bombesin](https://file.medchemexpress.com/product_pic/hy-103282.gif)
HY-103282
[D-Phe12]-BombesinBombesin Receptor Antagonist
Publications Citing Use of MedChemExpress (MCE) BIM 23042
More
Actividad biológica
Descripciòn
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice were 25-30 g male C57BL/6[2]
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Dosage:10 μg
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Administration:IV; a single bolus
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Result:Attenuated neurogenic swelling and thermal and mechanical sensitization.
Chemical Information
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No. CAS 111857-96-6
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Peso molecular 1192.45
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Fòrmula C63H73N11O9S2
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Sequence
{DNal}-Cys-Tyr-{DTrp}-Lys-Val-Cys-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
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Sequence Shortening
{DNal}-CY-{DTrp}-KVC-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
Bombesin improves visceral hypersensitivity and colonic hyperpermeability via BB1 receptor-dependent multi-pathway mechanisms in a rat model of irritable bowel syndrome. [Abstract]2026 Feb 15:1015:178566. PMID: 41548687
Solvente y solubilidad
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Pureza y Documentación
Referencias
[1]. R R Ryan, et al. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14. [Content Brief]
[2]. Santosh K Mishra, et al. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. [Content Brief]
[3]. M Orbuch, et al. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol Pharmacol. 1993 Oct;44(4):841-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BIM 23042 Related Classifications
HY-103277 Related Classifications
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