1. GPCR/G Protein
  2. CRFR
  3. Urocortin, rat TFA

Urocortin, rat TFA (Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)

Cat. No.: HY-P1296A
Handling Instructions

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively.

For research use only. We do not sell to patients.

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Urocortin, rat TFA Chemical Structure

Urocortin, rat TFA Chemical Structure

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Description

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively[1][2].

IC50 & Target

Ki: 13 nM (Human CRF1), 1.5 nM (Rat CRF), and 0.97 nM (Mouse CRF)[1]

In Vitro

Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF and mouse CRF, respectively in stably transfected Chinese hamster ovary cells[2].

In Vivo

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3].

Molecular Weight

4821.28

Formula

C₂₀₈H₃₃₉N₆₂F₃O₆₆

Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Urocortin, ratUrocortin (Rattus norvegicus) (TFA)Rat urocortinCRFRCorticotropin-releasing Factor ReceptorcAMPCRF1CRF2αmCRF2βneuropeptideendogenousfoodintakeTFAInhibitorinhibitorinhibit

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Urocortin, rat TFA
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HY-P1296A
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