1. GPCR/G Protein
  2. CRFR
  3. Urocortin, rat TFA

Urocortin, rat TFA  (Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)

Cat. No.: HY-P1296A
Handling Instructions

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively.

For research use only. We do not sell to patients.

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Urocortin, rat TFA Chemical Structure

Urocortin, rat TFA Chemical Structure

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Description

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively[1][2].

IC50 & Target

Ki: 13 nM (Human CRF1), 1.5 nM (Rat CRF), and 0.97 nM (Mouse CRF)[1]

In Vitro

Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF and mouse CRF, respectively in stably transfected Chinese hamster ovary cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

4821.28

Formula

C208H339N62F3O66

Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Urocortin, rat TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Urocortin, rat TFA
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HY-P1296A
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