1. GPCR/G Protein
  2. CRFR
  3. Urocortin, rat

Urocortin, rat  (Synonyms: Urocortin (Rattus norvegicus); Rat urocortin)

Cat. No.: HY-P1296 Purity: 98.50%
COA Handling Instructions

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively.

For research use only. We do not sell to patients.

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Urocortin, rat Chemical Structure

Urocortin, rat Chemical Structure

CAS No. : 171543-83-2

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5 mg USD 420 In-stock
10 mg USD 630 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively[1][2].

IC50 & Target

CRFR1

 

CRFR2

 

In Vitro

Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF and mouse CRF, respectively in stably transfected Chinese hamster ovary cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

4707.26

Formula

C206H338N62O64

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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Urocortin, rat Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Urocortin, rat
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