1. GPCR/G Protein
  2. CRFR

Urocortin, rat (Synonyms: Urocortin (Rattus norvegicus); Rat urocortin; )

Cat. No.: HY-P1296
Handling Instructions

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF and mCRF, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Urocortin, rat Chemical Structure

Urocortin, rat Chemical Structure

CAS No. : 171543-83-2

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5 mg USD 990 Get quote

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Description

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF and mCRF, respectively.

IC50 & Target

Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)[1]

In Vitro

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1].

In Vivo

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].

References
Molecular Weight

4707.26

Formula

C₂₀₆H₃₃₈N₆₂O₆₄

CAS No.

171543-83-2

Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Urocortin, rat
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HY-P1296
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Urocortin, rat

Cat. No.: HY-P1296