Helospectin II
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
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- CAS 番号: 93585-83-2
- 分子式: C180H288N46O57
- 分子量:4008.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Vasoactive intestinal peptide (VIP) receptor[1]
Helospectin II (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch[1].
Helospectin II relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.93[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[2]
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Dosage:0.03, 0.3, 1, 2 nmol/kg
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Administration:100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
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Result:Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
化学情報
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CAS 番号 93585-83-2
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分子量 4008.55
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分子式 C180H288N46O57
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配列
His-Ser-Asp-Ala-Thr-Phe-Thr-Ala-Glu-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-Ser-Pro-Arg-Pro-Pro-Ser
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シーケンスの短縮
HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPS
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tsueshita T, et al. Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. [Content Brief]
[2]. Grundemar L, et al. Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol. 1990 Mar;99(3):526-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Helospectin II 関連分類
HY-P3050 関連分類
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