Orphan GPCR SP9155 agonist P550 (mouse, rat)  (Synonyms: 26RFa (mouse, rat))

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27^[1][2].

26RFa is a key neuropeptide in the regulation of energy metabolism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2820.17

C₁₂₆H₁₉₅N₃₇O₃₇

600171-70-8

Ala-Ser-Gly-Pro-Leu-Gly-Thr-Leu-Ala-Glu-Glu-Leu-Ser-Ser-Tyr-Ser-Arg-Arg-Lys-Gly-Gly-Phe-Ser-Phe-Arg-Phe-NH2

ASGPLGTLAEELSSYSRRKGGFSFRF-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252.  [Content Brief]

  [2]. Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29.  [Content Brief]

  [3]. Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730.  [Content Brief]