2. Stem Cell/Wnt GPCR/G Protein Neuronal Signaling
  3. Wnt Neuropeptide Y Receptor
  4. BIBO3304 diTFA

BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.

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CAS No. : 2310085-85-7

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BIBO3304 diTFA Related Antibodies

Top Publications Citing Use of Products

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074.  [Abstract]

    Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons.

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074.  [Abstract]

    NPY (10 μM) induced outward currents were recorded and inhibited by BIBO3304(2 μM) from GRP+ interneurons in the SDH from GrpCre;Ai9 mice.

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: In Vivo. 2024 May-Jun;38(3):1133-1142.  [Abstract]

    Hypothalamic NPY exerted an antinociceptive effect by binding to Y1R and Y2R in cancer-bearing rats. PWT was measured using von Frey filaments (BIBO3304: 3 μg).

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    Description

    BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway[1][2][3].

    Molecular Weight

    757.68

    Formula

    C33H37F6N7O7
    CAS No.
    SMILES

    O=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BIBO3304 diTFA Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BIBO3304 diTFA2310085-85-7WntNeuropeptide Y ReceptorNPY receptorNeuropeptide YY1 receptorWnt signalingInhibitorinhibitorinhibit

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