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BIBO3304 free base

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Based on 4 publication(s) in Google Scholar

BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting.

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  • CAS No.: 191868-13-0
  • Formule: C29H35N7O3
  • Masse moléculaire:529.63
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  • BIBO3304 free base Chemical Structure
    BIBO3304 free base Chemical Structure
  • Experimental Validation Results for BIBO3304 free base
  • Experimental Validation Results for BIBO3304 free base
  • Experimental Validation Results for BIBO3304 free base
CAS No.: 191868-13-0
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  • BIBO3304 free base Chemical Structure
    BIBO3304 free base Chemical Structure
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  • 1/16

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]

    Customer Validation
     Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons.

  • 1/16

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]

    Customer Validation
     NPY (10 μM) induced outward currents were recorded and inhibited by BIBO3304(2 μM) from GRP+ interneurons in the SDH from GrpCre;Ai9 mice.

  • 1/16

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: In Vivo. 2024 May-Jun;38(3):1133-1142. [Abstract]

    Customer Validation
     Hypothalamic NPY exerted an antinociceptive effect by binding to Y1R and Y2R in cancer-bearing rats. PWT was measured using von Frey filaments (BIBO3304: 3 μg).

  • BIBO3304 free base