2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. BIBO3304 free base

BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting.

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CAS No. : 191868-13-0

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Top Publications Citing Use of Products

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074.  [Abstract]

    Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons.

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074.  [Abstract]

    NPY (10 μM) induced outward currents were recorded and inhibited by BIBO3304(2 μM) from GRP+ interneurons in the SDH from GrpCre;Ai9 mice.

    BIBO3304 free base purchased from MedChemExpress. Usage Cited in: In Vivo. 2024 May-Jun;38(3):1133-1142.  [Abstract]

    Hypothalamic NPY exerted an antinociceptive effect by binding to Y1R and Y2R in cancer-bearing rats. PWT was measured using von Frey filaments (BIBO3304: 3 μg).

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    Description

    BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting[1].

    Molecular Weight

    529.63

    Formula

    C29H35N7O3
    CAS No.
    SMILES

    O=C([C@@H](CCC/N=C(N)\N)NC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O)NCC3=CC=C(C=C3)CNC(N)=O
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BIBO3304 free base Related Classifications

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    Keywords:

    BIBO3304191868-13-0BIBO 3304BIBO-3304Neuropeptide Y ReceptorNPY receptorNonpeptidesubnanomolar affinityfood intakefastingNPYInhibitorinhibitorinhibit

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