Neuropeptide Y (3-36) (porcine)
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
For research use only. We do not sell to patients.
- CAS No.: 143863-88-1
- Formula: C176H271N53O54
- Molecular Weight:3993.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Neuropeptide Y Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[3]|
NPY Y2 receptor |
In Vitro
Neuropeptide Y (3-36) (porcine) accounts for 35% of NPY-like immunoreactivity in porcine brain[2].
Neuropeptide Y (3-36) (porcine) shows high affinity for Y2-like receptors on CHP234 cells, and light affinity Y1-like receptors on SK-N-MC cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats (250-300 g)[1]
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Dosage:0.24, 0.72, 2.4, 7.2, 24 nM per animal
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Administration:Intracerebroventricular injection; single dose
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Result:Stimulated rat feeding dose-dependently.
Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.
Chemical Information
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CAS No. 143863-88-1
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Molecular Weight 3993.36
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Formula C176H271N53O54
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Sequence Shortening
SKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. O'Shea D, et al. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. 1997 Jan;138(1):196-202. [Content Brief]
[2]. Grandt D, et al. Neuropeptide Y 3-36 is an endogenous ligand selective for Y2 receptors. Regul Pept. 1996 Nov 14;67(1):33-7. [Content Brief]
[3]. M Aldegunde, et al. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss), Peptides. 2006; 27(4):719-727. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuropeptide Y (3-36) (porcine) Related Classifications
HY-P3676 Related Classifications
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