2. GPCR/G Protein
  3. CRFR
  4. Sauvagine TFA

Sauvagine TFA is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine TFA activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine TFA can be used for research on central nervous system and blood diseases.

For research use only. We do not sell to patients.

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Sauvagine TFA

Sauvagine TFA Chemical Structure

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Other Forms of Sauvagine TFA:

Sauvagine TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Sauvagine TFA is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine TFA activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine TFA can be used for research on central nervous system and blood diseases[1][2][3].

In Vitro

Sauvagine (0.001-1000 nM; 20 min) TFA potently stimulates intracellular cAMP accumulation in HM-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.1 nM[1].
Sauvagine (0.001-100 nM; 20 min) TFA stimulates intracellular cAMP accumulation in PC-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sauvagine TFA Related Antibodies
In Vivo

Sauvagine (i.c.v or i.c. or i.v.; single dose) TFA elevates plasma ACTH, catecholamine and glucose concentrations in rats[2].
Sauvagine (i.v.; single dose) TFA increases superior mesenteric artery flow and plasma glucose, and decrease mean arterial pressure in conscious dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

4713.33

Formula

C204H347F3N56O65S1
Appearance

Solid

Color

White to off-white

Sequence

{Pry}-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2 (TFA)
Sequence Shortening

{Pry}GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (21.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2122 mL 1.0608 mL 2.1216 mL
5 mM 0.0424 mL 0.2122 mL 0.4243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2122 mL 1.0608 mL 2.1216 mL 5.3041 mL
5 mM 0.0424 mL 0.2122 mL 0.4243 mL 1.0608 mL
10 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
15 mM 0.0141 mL 0.0707 mL 0.1414 mL 0.3536 mL
20 mM 0.0106 mL 0.0530 mL 0.1061 mL 0.2652 mL
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Sauvagine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SauvagineCRFRCorticotropin-releasing Factor ReceptorCRHRHM-CRF receptorPC-CRF receptorACTH293-EBNA cellsα-helical CRF-(9-41)CV-1 cellscorticotropin-releasing factorhypothalamic-pituitary-adrenal axisβ-endorphinintracellular cAMPInhibitorinhibitorinhibit

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