1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. Galanin Receptor Ligand M35 TFA

Galanin Receptor Ligand M35 TFA 

Cat. No.: HY-P1840A
Handling Instructions

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

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Galanin Receptor Ligand M35 TFA Chemical Structure

Galanin Receptor Ligand M35 TFA Chemical Structure

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Other Forms of Galanin Receptor Ligand M35 TFA:

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Description

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2].

In Vitro

Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1].

In Vivo

Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[3].

Molecular Weight

2347.62

Formula

C₁₀₉H₁₅₄N₂₇F₃O₂₈

Sequence

{Gly}{Trp}{Thr}{Leu}{Asn}{Ser}{Ala}{Gly}{Tyr}{Leu}{Leu}{Gly}{Pro}{Pro}{Pro}{Gly}{Phe}{Ser}{Pro}{Phe}{Arg}-NH2

Sequence Shortening

GWTLNSAGYLLGPPPGFSPFR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Galanin Receptor Ligand M35Galanin Receptor Ligand M 35Galanin Receptor Ligand M-35Neuropeptide Y ReceptorNPY receptorneuropeptidehigh-affinityRin5FinsulinomacellsligandAlzheimer’sdiseaseInhibitorinhibitorinhibit

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Galanin Receptor Ligand M35 TFA
Cat. No.:
HY-P1840A
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