1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. Galanin Receptor Ligand M35

Galanin Receptor Ligand M35 

Cat. No.: HY-P1840
Handling Instructions

Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

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Galanin Receptor Ligand M35 Chemical Structure

Galanin Receptor Ligand M35 Chemical Structure

CAS No. : 142846-71-7

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Description

Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2].

IC50 & Target

Kd: 0.1 nM (galanin receptor)[1]
Ki: 0.11 nM (human galanin receptor type 1), 2.0 nM (human galanin receptor type 2)[2]

In Vitro

Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1].

In Vivo

Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[1].

Molecular Weight

2233.60

Formula

C₁₀₇H₁₅₃N₂₇O₂₆

CAS No.

142846-71-7

Sequence

{Gly}{Trp}{Thr}{Leu}{Asn}{Ser}{Ala}{Gly}{Tyr}{Leu}{Leu}{Gly}{Pro}{Pro}{Pro}{Gly}{Phe}{Ser}{Pro}{Phe}{Arg}-NH2

Sequence Shortening

GWTLNSAGYLLGPPPGFSPFR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

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Galanin Receptor Ligand M35
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HY-P1840
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