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  2. GR 82334

GR 82334 

Cat. No.: HY-P1193
Handling Instructions

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

For research use only. We do not sell to patients.

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GR 82334 Chemical Structure

GR 82334 Chemical Structure

CAS No. : 129623-01-4

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Description

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].

In Vivo

GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1].
GR 82334 (10 nM-1 µM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2].

Animal Model: 3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
Dosage: 10 nM, 100 nM, and 1 µM
Administration: Lntrathecal injection between vertebrae L4 and L5 
Result: Increased heat-induced foot withdrawal latency in mice.
Molecular Weight

1386.55

Formula

C₆₉H₉₁N₁₅O₁₆

CAS No.

129623-01-4

Sequence Shortening

{Glp}ADPNKFY-{Aaa}-LW-NH2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GR 82334GR82334GR-82334Otherstachykinin NK1neuropeptideneurokinin antagonistInhibitorinhibitorinhibit

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