BChE-IN-8
BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- CAS No.: 2653349-78-9
- Formula: C18H12BrN7O2
- Molecular Weight:438.24
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.15 ± 0.10 nM (eqBChE), 45.2 ± 45.0 nM (hBChE) [1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
27.84 μM
Compound: 20
|
Cytotoxicity against mouse BV-2 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
|
[PMID: 35728508] |
Chemical Information
-
CAS No. 2653349-78-9
-
Molecular Weight 438.24
-
Formula C18H12BrN7O2
-
SMILES
O=C(NC1=CC(C#N)=CC(Br)=C1)CN2C3=CC=CC=C3N=C2C4=NON=C4N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-8 Related Classifications
HY-147859 Related Classifications
Powered by Bioz