2653349-78-9
Chemical Structure
BChE-IN-8
- CAS No.: 2653349-78-9
- Formula:C18H12BrN7O2
- Molecular Weight:438.24
IUPAC Name: 2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(3-bromo-5-cyanophenyl)acetamide
InChIKey: IFFSXCHPOGNWKL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C#N)=CC(Br)=C1)CN2C3=CC=CC=C3N=C2C4=NON=C4N
Biological Activity: BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1].
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BChE-IN-8 | BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research. | |||||||||||||||||||||
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Keywords
