1. GPCR/G Protein
  2. CRFR
  3. Urotensin I

Urotensin I (Synonyms: Catostomus urotensin I)

Cat. No.: HY-P1542
Handling Instructions

Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF and mCRF receptors, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Urotensin I Chemical Structure

Urotensin I Chemical Structure

CAS No. : 83930-33-0

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Description

Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF and mCRF receptors, respectively.

IC50 & Target

pEC50: 11.46 (human CRF1, CHO cells), 9.36 (human CRF2, CHO cells), 9.85 (rat CRF, CHO cells)[1]
Ki: 0.4 nM (hCRF1, cell assay), 1.8 nM (rCRF, cell assay), and 5.7 nM (mCRF, cell assay)[2]

In Vitro

Urotensin I is a 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF receptors in CHO cells[1] and with Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF and mCRF receptors in cell assay, respectively[2]. Urotensin I exhibits a striking sequence homology with ovine corticotropin-releasing factor and with frog sauvagine, and has potent hypotensive activity and corticotropin-releasing activity[3]. Urotensin I stimulates the release of ACTH from an isolated dispersed goldfish anterior pituitary cell column[4].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

4869.46

Formula

C₂₁₀H₃₄₀N₆₂O₆₇S₂

CAS No.

83930-33-0

Sequence

Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2

Sequence Shortening

NDDPPISIDLTFHLLRNMIEMARIENEREQAGLNRKYLDEV-NH2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Urotensin I
Cat. No.:
HY-P1542
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Urotensin I

Cat. No.: HY-P1542