1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. CIM0216

CIM0216 

Cat. No.: HY-110220 Purity: ≥98.0%
Handling Instructions

CIM0216, a synthetic TRPM3 ligand, acts as a potent and selective agonist of TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts in a TRPM3-dependent manner to induce pain and evoke neuropeptide release from sensory nerve terminals in vitro. CIM0216 is a powerful tool for studies of the physiological functions of TRPM3, and can be used for neurogenic inflammation research.

For research use only. We do not sell to patients.

CIM0216 Chemical Structure

CIM0216 Chemical Structure

CAS No. : 1031496-06-6

Size Price Stock Quantity
5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Description

CIM0216, a synthetic TRPM3 ligand, acts as a potent and selective agonist of TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts in a TRPM3-dependent manner to induce pain and evoke neuropeptide release from sensory nerve terminals in vitro. CIM0216 is a powerful tool for studies of the physiological functions of TRPM3, and can be used for neurogenic inflammation research[1].

IC50 & Target[1]

TRPM3

 

In Vitro

CIM0216 elicits a dose-dependent Ca2+ response [pEC50=0.77±0.1 µM] in HEK-TRPM3 cells, which is not observed in nontransfected HEK293 cells. CIM0216 induces a robust increase in intracellular Ca2+ concentration (1,145±26 nM) in single-cell FURA2-ratiometric Ca2+ imaging in HEK-TRPM3 cells. These responses are not observed in nontransfected HEK cells or in the absence of extracellular Ca2+[1].
CIM0216 (10 µM) has no stimulating/blocking effect on TRPM1, TRPM4, TRPM6, or TRPM7 currents; however, a small blocking effect of CIM0216 is observed after activation of TRPM2 (16.6% block) and TRPM5 (33.5% block). CIM0216 also has no detectable effect on human TRPV1 and TRPM8 channel activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

347.41

Formula

C₂₁H₂₁N₃O₂

CAS No.
SMILES

CC1=CC(NC(C(C2=CC=CC=C2)N3C4=CC=CC=C4CCC3)=O)=NO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (100.75 mM; Need ultrasonic and warming)

Ethanol : 17 mg/mL (48.93 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8784 mL 14.3922 mL 28.7844 mL
5 mM 0.5757 mL 2.8784 mL 5.7569 mL
10 mM 0.2878 mL 1.4392 mL 2.8784 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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Keywords:

CIM0216CIM 0216CIM-0216TRP ChannelTransient receptor potential channelsTRPM3neurogenicinflammationsensory nerveInhibitorinhibitorinhibit

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CIM0216
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