Neuropeptide S (human) 

Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research^[1].

EC50: 9.4 nM (neuropeptide S receptor)^[1]

Half-maximal effective concentrations (EC₅₀) for mobilization of [Ca²⁺]_i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively^[1].
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC₅₀ of 6.7 nM, the binding of [^125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K_d = 0.33 nM)^[1].
Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [^125II] Y10-NPS, [^125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC₅₀ = 0.42 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2187.48

C₉₃H₁₅₅N₃₁O₂₈S

412938-67-1

Solid

White to off-white

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser

SFRNGVGTGMKKTSFQRAKS

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.  [Content Brief]