Neuropeptide S (human)
Based on 1 Customer Validation
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 412938-67-1
- Formula: C93H155N31O28S
- Molecular Weight:2187.48
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 9.4 nM (neuropeptide S receptor)[1]
Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively[1]. Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM)[1]. Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS, [125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57Bl/6 mice[1]
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Dosage:0.1 nM, 1 nM
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Administration:Intracerebroventricular (i.c.v.) injection
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Result:Increased locomotor activity and promoted wakefulness.
Chemical Information
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CAS No. 412938-67-1
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Appearance Solid
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Molecular Weight 2187.48
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Formula C93H155N31O28S
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Color White to off-white
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Sequence
Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
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Sequence Shortening
SFRNGVGTGMKKTSFQRAKS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : ≥ 50 mg/mL (22.86 mM)
DMSO : 20 mg/mL (9.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.4571 mL | 2.2857 mL | 4.5715 mL | 11.4287 mL |
| 5 mM | 0.0914 mL | 0.4571 mL | 0.9143 mL | 2.2857 mL | |
| H2O | 10 mM | 0.0457 mL | 0.2286 mL | 0.4571 mL | 1.1429 mL |
| 15 mM | 0.0305 mL | 0.1524 mL | 0.3048 mL | 0.7619 mL | |
| 20 mM | 0.0229 mL | 0.1143 mL | 0.2286 mL | 0.5714 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Neuropeptide S (human) Related Classifications
HY-P1389 Related Classifications
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