1. Peptides
  2. Neuropeptide S (human)

Neuropeptide S (human) 

Cat. No.: HY-P1389
Handling Instructions

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neuropeptide S (human) Chemical Structure

Neuropeptide S (human) Chemical Structure

CAS No. : 412938-67-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Neuropeptide S (human):

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

IC50 & Target

EC50: 9.4 nM (neuropeptide S receptor)[1]

In Vitro

Neuropeptide S (human)(4 pM to 1.7 nM; 48 hours)retains full agonist activity with an EC50 of 6.7 ± 2.4 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 ± 0.12 nM)[1].
Neuropeptide S (human)(1 pM - 3 μM; 48 hours) are used to compete with 0.15 nM [125I] Y10-NPS, [125I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 ± 0.12 nM) [1].

In Vivo

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nMor 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.

Molecular Weight

2187.50

Formula

C₉₃H₁₅₅N₃₁O₂₈S

CAS No.

412938-67-1

Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser

Sequence Shortening

SFRNGVGTGMKKTSFQRAKS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Neuropeptide S (human)Othersanxietysleeplocomotor activityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Neuropeptide S (human)
Cat. No.:
HY-P1389
Quantity:
MCE Japan Authorized Agent: