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Cat. No.: HY-P1389A

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Neuropeptide S (human) TFA

Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research.

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Formule: C₉₃H₁₅₅N₃₁O₂₈S.xC₂HF₃O₂
Masse moléculaire:2187.48 (free acid)

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Neuropeptide S (human) TFA Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research^[1].

IC₅₀ & Target

EC50: 9.4 nM (neuropeptide S receptor)^[1]

In Vitro

Half-maximal effective concentrations (EC₅₀) for mobilization of [Ca²⁺]_i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively^[1].
Neuropeptide S (human) (4 pM-1.7 nM; 48 hours) retains full agonist activity with an EC₅₀ of 6.7 nM, the binding of [^125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K_d = 0.33 nM)^[1].
Neuropeptide S (human) (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [^125II] Y10-NPS, [^125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC₅₀ = 0.42 nM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nM or 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57Bl/6 mice ^[1]
Dosage:

0.1 nM or 1 nM
Administration:

Intracerebroventricular (i.c.v.) injection
Result:

Increased locomotor activity and promoted wakefulness.

Chemical Information

Masse moléculaire 2187.48 (free acid)
Formule C₉₃H₁₅₅N₃₁O₂₈S.xC₂HF₃O₂
Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
Sequence Shortening

SFRNGVGTGMKKTSFQRAKS
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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