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Cat. No.: HY-P1389A

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Neuropeptide S (human) TFA

Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

Formula: C₉₃H₁₅₅N₃₁O₂₈S.xC₂HF₃O₂
Molecular Weight:2187.48 (free acid)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Neuropeptide S (human) TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research^[1].

IC₅₀ & Target

EC50: 9.4 nM (neuropeptide S receptor)^[1]

In Vitro

Half-maximal effective concentrations (EC₅₀) for mobilization of [Ca²⁺]_i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively^[1].
Neuropeptide S (human) (4 pM-1.7 nM; 48 hours) retains full agonist activity with an EC₅₀ of 6.7 nM, the binding of [^125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K_d = 0.33 nM)^[1].
Neuropeptide S (human) (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [^125II] Y10-NPS, [^125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC₅₀ = 0.42 nM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nM or 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57Bl/6 mice ^[1]
Dosage:

0.1 nM or 1 nM
Administration:

Intracerebroventricular (i.c.v.) injection
Result:

Increased locomotor activity and promoted wakefulness.

Chemical Information

Molecular Weight 2187.48 (free acid)
Formula C₉₃H₁₅₅N₃₁O₂₈S.xC₂HF₃O₂
Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
Sequence Shortening

SFRNGVGTGMKKTSFQRAKS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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