1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Opioid Receptor
    iGluR

Dynorphin A (1-10) TFA 

Cat. No.: HY-P1594A Purity: 95.04%
Handling Instructions

Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dynorphin A (1-10) TFA Chemical Structure

Dynorphin A (1-10) TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 560 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Dynorphin A (1-10) TFA:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.

IC50 & Target

κ-opioid receptor[1]
IC50: 42.0 μM (NMDA receptor)[2]

In Vitro

Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2].

References
Molecular Weight

1348.48

Formula

C₅₉H₉₂F₃N₁₉O₁₄

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

Sequence Shortening

YGGFLRRIRP

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Dynorphin A (1-10) TFA
Cat. No.:
HY-P1594A
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Dynorphin A (1-10) TFA

Cat. No.: HY-P1594A