1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Opioid Receptor
    iGluR
  3. Dynorphin A 1-10

Dynorphin A 1-10 

Cat. No.: HY-P1594
Handling Instructions

Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

For research use only. We do not sell to patients.

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Dynorphin A 1-10 Chemical Structure

Dynorphin A 1-10 Chemical Structure

CAS No. : 79994-24-4

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Description

Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

IC50 & Target

κ-opioid receptor[1]
NMDA receptor[2]

In Vitro

Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2].

Molecular Weight

1234.45

Formula

C₅₇H₉₁N₁₉O₁₂

CAS No.

79994-24-4

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

Sequence Shortening

YGGFLRRIRP

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Storage

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Dynorphin A 1-10
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HY-P1594
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