2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Fosaprepitant

Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

For research use only. We do not sell to patients.

Fosaprepitant Chemical Structure

Fosaprepitant Chemical Structure

CAS No. : 172673-20-0

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Fosaprepitant Related Antibodies

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Description

Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

IC50 & Target

Neurokinin-1 receptor[1]
In Vivo

Fosaprepitant (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection, daily, for 7 days
Result: Increased the antinociceptive effect of morphine compared to control group.
Clinical Trial
Molecular Weight

614.41

Formula

C23H22F7N4O6P
CAS No.
SMILES

O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fosaprepitant Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosaprepitant172673-20-0L-758298L758298L 758298Neurokinin ReceptorNK receptorTachykinin receptorAprepitantnociceptionchemotherapy-inducednauseavomitingsubstance-PreceptorantagonistneuropeptideInhibitorinhibitorinhibit

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