1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Fosaprepitant

Fosaprepitant (Synonyms: L-758298)

Cat. No.: HY-14407
Handling Instructions

Fosaprepitant (L-785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

For research use only. We do not sell to patients.

Fosaprepitant Chemical Structure

Fosaprepitant Chemical Structure

CAS No. : 172673-20-0

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Description

Fosaprepitant (L-785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

IC50 & Target

Neurokinin-1 receptor[1]

In Vivo

Fosaprepitant (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection, daily, for 7 days
Result: Increased the antinociceptive effect of morphine compared to control group.
Clinical Trial
Molecular Weight

614.41

Formula

C₂₃H₂₂F₇N₄O₆P

CAS No.
SMILES

O=C1N=C(CN2[[email protected]@H](C3=CC=C(F)C=C3)[[email protected]@H](O[[email protected]](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FosaprepitantL-758298L758298L 758298Neurokinin ReceptorNK receptorAprepitantnociceptionchemotherapy-inducednauseavomitingsubstance-PreceptorantagonistneuropeptideInhibitorinhibitorinhibit

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Fosaprepitant
Cat. No.:
HY-14407
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