1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Fosaprepitant dimeglumine

Fosaprepitant dimeglumine (Synonyms: MK-0517; L785298)

Cat. No.: HY-14407A Purity: 98.05%
Handling Instructions

Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

For research use only. We do not sell to patients.

Fosaprepitant dimeglumine Chemical Structure

Fosaprepitant dimeglumine Chemical Structure

CAS No. : 265121-04-8

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5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
50 mg USD 270 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fosaprepitant dimeglumine:

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Description

Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

IC50 & Target

Neurokinin-1 receptor[1]

In Vivo

Fosaprepitant dimeglumine (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection, daily, for 7 days
Result: Increased the antinociceptive effect of morphine compared to control group.
Clinical Trial
Molecular Weight

1004.83

Formula

C₃₇H₅₆F₇N₆O₁₆P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (49.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9952 mL 4.9760 mL 9.9519 mL
5 mM 0.1990 mL 0.9952 mL 1.9904 mL
10 mM 0.0995 mL 0.4976 mL 0.9952 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Fosaprepitant dimeglumine
Cat. No.:
HY-14407A
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