1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Fosaprepitant dimeglumine

Fosaprepitant dimeglumine (Synonyms: MK-0517; L785298)

Cat. No.: HY-14407A Purity: >99.0%
Handling Instructions

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.

For research use only. We do not sell to patients.

Fosaprepitant dimeglumine Chemical Structure

Fosaprepitant dimeglumine Chemical Structure

CAS No. : 265121-04-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
50 mg USD 270 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fosaprepitant dimeglumine:

Top Publications Citing Use of Products

Publications Citing Use of MCE Fosaprepitant dimeglumine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. IC50 Value: Target: NK1 receptor in vitro: Fosaprepitant (also known as MK-0517 and L-758,298) is a water-soluble phosphoryl prodrug for aprepitant, which, when administered intravenously, is converted to aprepitant within 30 min of intravenous administration via the action of ubiquitous phosphatases. Owing to the rapid conversion offosaprepitant to the active form (aprepitant), fosaprepitant 115 mg provided the same aprepitant exposure in terms of AUC as aprepitant 12 mg orally, and fosaprepitant is expected to provide a correspondingly similar antiemetic effect as aprepitant [1]. in vivo: Fosaprepitant is well tolerated with mild to moderate venous irritation being the only additional toxicity to those seen with oral aprepitant, and that is a function of dose, concentration, and infusion rate [2]. Patients receiving cisplatin ≥ 70 mg/m(2) for the first time received ondansetron and dexamethasone with a standard aprepitant regimen (125 mg on day 1, 80 mg on day 2, 80 mg on day 3) or a single-dose fosaprepitant regimen (150 mg on day 1) [3]. Single-dose fosaprepitant used in combination with granisetron and dexamethasone was well-tolerated and effective in preventing chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic cancer chemotherapy, including high-dose cisplatin [4].

Clinical Trial
Molecular Weight







O=C1N=C(CN2[[email protected]@H](C3=CC=C(F)C=C3)[[email protected]@H](O[[email protected]](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O.OC[[email protected]@H](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)CNC.OC[[email protected]@H](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)CNC


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (49.76 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9952 mL 4.9760 mL 9.9519 mL
5 mM 0.1990 mL 0.9952 mL 1.9904 mL
10 mM 0.0995 mL 0.4976 mL 0.9952 mL
*Please refer to the solubility information to select the appropriate solvent.
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


Fosaprepitant dimeglumineMK-0517 L785298MK0517MK 0517L785298L 785298L-785298Neurokinin ReceptorNK receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name



Applicant name *


Email address *

Phone number *


Organization name *

Country or Region *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product name:
Fosaprepitant dimeglumine
Cat. No.:
MCE Japan Authorized Agent: