1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Fosaprepitant-d4 dimeglumine

Fosaprepitant-d4 dimeglumine (Synonyms: MK-0517-d4; L785298-d4)

Cat. No.: HY-14407AS
Handling Instructions

Fosaprepitant-d4 (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

For research use only. We do not sell to patients.

Fosaprepitant-d4 dimeglumine Chemical Structure

Fosaprepitant-d4 dimeglumine Chemical Structure

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Description

Fosaprepitant-d4 (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1008.86

Formula

C37H52D4F7N6O16P

SMILES

OC[[email protected]@H](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)CNC.C[[email protected]](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[[email protected]@H](OC([2H])([2H])C2([2H])[2H])[[email protected]@](C3=CC=C(C=C3)F)([H])N2CC4=NN(C(N4)=O)P(O)(O)=O.OC[[email protected]@H](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)CNC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Fosaprepitant-d4 dimeglumine
Cat. No.:
HY-14407AS
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