Urocortin, human  (Synonyms: Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I)

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF₂ receptor, with K_is of 0.4, 0.3, and 0.5 nM for hCRF₁, rCRF_2α and mCRF_2β, respectively.

Ki: 0.4 nM (hCRF₁, cell assay), 0.3 nM (rCRF_2α, cell assay), and 0.5 nM (mCRF_2β, cell assay)^[1]

Urocortin, human is a selective agonist of CRF₂ receptor, with K_is of 0.4, 0.3, and 0.5 nM for human CRF₁, rat CRF_2α and mouse CRF_2β receptors in cell assay, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4696.24

C₂₀₄H_337N63O64

176591-49-4

Solid

White to off-white

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.  [Content Brief]

  [2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.  [Content Brief]