1. GPCR/G Protein
  2. CRFR
  3. Urocortin, human

Urocortin, human (Synonyms: Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I)

Cat. No.: HY-P1295
Handling Instructions

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF and mCRF, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Urocortin, human Chemical Structure

Urocortin, human Chemical Structure

CAS No. : 176591-49-4

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500 μg USD 170 Get quote
1 mg USD 270 Get quote
5 mg USD 940 Get quote

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Description

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF and mCRF, respectively.

IC50 & Target

Ki: 0.4 nM (hCRF1, cell assay), 0.3 nM (rCRF, cell assay), and 0.5 nM (mCRF, cell assay)[1]

In Vitro

Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF and mouse CRF receptors in cell assay, respectively[1].

In Vivo

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

4696.24

Formula

C₂₀₄H₃₃₇N₆₃O₆₄

CAS No.

176591-49-4

Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Sequence Shortening

DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Shipping

Room temperature in continental US; may vary elsewhere

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Urocortin, human
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HY-P1295
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Urocortin, human

Cat. No.: HY-P1295