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  3. Neuropeptide W-23 (human) (TFA)

Neuropeptide W-23 (human) (TFA)  (Synonyms: NPW-23 TFA)

Cat. No.: HY-P1035A
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Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

For research use only. We do not sell to patients.

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Neuropeptide W-23 (human) (TFA) Chemical Structure

Neuropeptide W-23 (human) (TFA) Chemical Structure

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Neuropeptide W-23 (human) (TFA) Related Antibodies

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Description

Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)[1].

IC50 & Target

NPBW1, NPBW2[1]
In Vitro

Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide W-23 (human) (TFA) Related Antibodies
In Vivo

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Harlan Sprague-Dawley rats, 250–300 g[2]
Dosage: 0.3, 1.0 and 3.0 nM
Administration: Intracerebroventricular injection, 2 μL
Result: Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model: Male Wistar rats weighing 250–300 g[3]
Dosage: 2, 4, 6 and 8 nM
Administration: Intra-cerebroventricular injection, 10 μL
Result: Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
Molecular Weight

2698.03

Formula

C119H183N35O28S.C2HF3O2
Sequence

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-LeuMet-Gly-Leu
Sequence Shortening

WYKHVASPRYHTVGRAAGLLMGL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide W-23 (human) (TFA)NPW-23NPW23NPW 23OthersNPBW1NPBW2GPR7GPR8Neuropeptide Whypetensionanorexigenic effectInhibitorinhibitorinhibit

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