Neuropeptide W-23 (human) TFA
Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
For research use only. We do not sell to patients.
- Formula: C119H183N35O28S.C2HF3O2
- Molecular Weight:2698.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NPBW1, NPBW2[1]
Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Harlan Sprague-Dawley rats, 250–300 g[2]
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Dosage:0.3, 1.0 and 3.0 nM
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Administration:Intracerebroventricular injection, 2 μL
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Result:Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
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Animal Model:Male Wistar rats weighing 250–300 g[3]
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Dosage:2, 4, 6 and 8 nM
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Administration:Intra-cerebroventricular injection, 10 μL
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Result:Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
Chemical Information
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Molecular Weight 2698.03
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Formula C119H183N35O28S.C2HF3O2
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Synonyms
NPW-23 TFA
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Sequence
Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-LeuMet-Gly-Leu
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Sequence Shortening
WYKHVASPRYHTVGRAAGLLMGL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42. [Content Brief]
[2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10. [Content Brief]
[3]. Naso T, et al. Central neuropeptide W has anorexigenic effect in rats. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuropeptide W-23 (human) TFA Related Classifications
HY-P1035A Related Classifications
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